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New Therapeutic Targets and Drugs for the Treatment of Asthma.

Authors :
Alves MF
da Fonseca DV
de Melo SAL
Scotti MT
Scotti L
Dos Santos SG
de Fatima Formiga Melo Diniz M
Source :
Mini reviews in medicinal chemistry [Mini Rev Med Chem] 2018; Vol. 18 (8), pp. 684-696.
Publication Year :
2018

Abstract

Asthma is an inflammatory disease which affects millions of people worldwide. Therefore, it is necessary to search for new sources of therapies for the treatment of these patients in order to improve their quality of life. From content analysis of literature of new therapeutic targets, there are various targets and drugs reported to be promising for the treatment of asthma. Interleukins involved in inflammatory processes are often presented as candidate targets for new drugs. The action of such therapeutics would not only affect interleukins, but also their receptors. Small molecules (e.g. ligustrazine and SP600125) and large molecule antibodies (e.g. lebrikizumab, benralizumab, dupilumab) are being considered as novel agents for the pharmacotherapy of asthma. Therefore, through this research, we can see advances in the search for new targets and promising drugs to treat asthma. It is expected that these new drug candidates will eventually be approved and marketed so that asthma patients can use them to enhance their quality of life.<br /> (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)

Details

Language :
English
ISSN :
1875-5607
Volume :
18
Issue :
8
Database :
MEDLINE
Journal :
Mini reviews in medicinal chemistry
Publication Type :
Academic Journal
Accession number :
28971769
Full Text :
https://doi.org/10.2174/1389557517666170927145011