Back to Search
Start Over
New Therapeutic Targets and Drugs for the Treatment of Asthma.
- Source :
-
Mini reviews in medicinal chemistry [Mini Rev Med Chem] 2018; Vol. 18 (8), pp. 684-696. - Publication Year :
- 2018
-
Abstract
- Asthma is an inflammatory disease which affects millions of people worldwide. Therefore, it is necessary to search for new sources of therapies for the treatment of these patients in order to improve their quality of life. From content analysis of literature of new therapeutic targets, there are various targets and drugs reported to be promising for the treatment of asthma. Interleukins involved in inflammatory processes are often presented as candidate targets for new drugs. The action of such therapeutics would not only affect interleukins, but also their receptors. Small molecules (e.g. ligustrazine and SP600125) and large molecule antibodies (e.g. lebrikizumab, benralizumab, dupilumab) are being considered as novel agents for the pharmacotherapy of asthma. Therefore, through this research, we can see advances in the search for new targets and promising drugs to treat asthma. It is expected that these new drug candidates will eventually be approved and marketed so that asthma patients can use them to enhance their quality of life.<br /> (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)
- Subjects :
- Antibodies, Monoclonal immunology
Antibodies, Monoclonal, Humanized therapeutic use
Asthma pathology
Humans
Immunoglobulin E immunology
Immunoglobulin E metabolism
Interleukins immunology
Interleukins metabolism
Protein Kinase Inhibitors chemistry
Protein Kinase Inhibitors metabolism
Protein Kinase Inhibitors therapeutic use
p38 Mitogen-Activated Protein Kinases antagonists & inhibitors
p38 Mitogen-Activated Protein Kinases metabolism
Antibodies, Monoclonal therapeutic use
Asthma drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1875-5607
- Volume :
- 18
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Mini reviews in medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 28971769
- Full Text :
- https://doi.org/10.2174/1389557517666170927145011