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Valbenazine for the treatment of tardive dyskinesia.

Authors :
Müller T
Source :
Expert review of neurotherapeutics [Expert Rev Neurother] 2017 Dec; Vol. 17 (12), pp. 1135-1144. Date of Electronic Publication: 2017 Oct 12.
Publication Year :
2017

Abstract

Introduction: Chronic intake of typical neuroleptics or centrally acting dopamine receptor blocking antiemetics may cause onset of tardive syndromes. Various types exist. One of them is tardive dyskinesia, characterised by often stigmatising, purposeless, rapid, repetitive, stereotypic, involuntary movements of face, limbs or trunk. Effective symptomatic drug treatment options beyond application of tetrabenazine are rare. Tetrabenazine is usually administered three times daily due to the short half life of this agent. Areas covered: This narrative review discusses the value of valbenazine for the treatment of tardive dyskinesia as a therapeutic alternative to tetrabenazine. Expert commentary: Valbenazine is a selective inhibitor of vesicular monoamine transporter 2, which is metabolized to (+)-alpha-dihydrotetrabenazine. Valbenazine and particularly its metabolite inhibit vesicular monoamine transporter 2 function. Once daily intake of valbenazine ameliorated the severity of tardive dyskinesia. The chiral purity of valbenazine circumvents generation of the (-)alpha and (+) and (-)beta dihydrotetrabenazine metabolites of tetrabenazine or deutetrabenazine. Valbenazine and its metabolite do not antagonize postsynaptic monoamine receptors in contrast to the tetrabenazine formulations. Therefore one may hypothesize that fewer and less severe motor and psychopathological side effects will occur during valbenazine long term application compared with tetrabenazine or deutretrabenazine.

Details

Language :
English
ISSN :
1744-8360
Volume :
17
Issue :
12
Database :
MEDLINE
Journal :
Expert review of neurotherapeutics
Publication Type :
Academic Journal
Accession number :
28971695
Full Text :
https://doi.org/10.1080/14737175.2017.1386556