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Management of gastric mucosa-associated lymphoid tissue lymphoma in patients with extra copies of the MALT1 gene.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2017 Sep 07; Vol. 23 (33), pp. 6155-6163. - Publication Year :
- 2017
-
Abstract
- Aim: To identify the clinical features of gastric mucosa-associated lymphoid tissue (MALT) lymphoma with extra copies of MALT1.<br />Methods: This is a multi-centered, retrospective study. We reviewed 146 patients with MALT lymphoma in the stomach who underwent fluorescence in situ hybridization analysis for t(11;18) translocation. Patients were subdivided into patients without t(11;18) translocation or extra copies of MALT1 (Group A, n = 88), patients with t(11;18) translocation (Group B, n = 27), and patients with extra copies of MALT1 (Group C, n = 31). The clinical background, treatment, and outcomes of each group were investigated.<br />Results: Groups A and C showed slight female predominance, whereas Group B showed slight male predominance. Mean ages and clinical stages at lymphoma diagnosis were not different between groups. Complete response was obtained in 61 patients in Group A (69.3%), 22 in Group B (81.5%), and 21 in Group C (67.7%). Helicobacter pylori (H. pylori) eradication alone resulted in complete remission in 44 patients in Group A and 13 in Group C. In Group B, 14 patients underwent radiotherapy alone, which resulted in lymphoma disappearance. Although the difference was not statistically significant, event-free survival in Group C tended to be inferior to that in Group A (P = 0.10).<br />Conclusion: Patients with t(11;18) translocation should be treated differently from others. Patients with extra copies of MALT1 could be initially treated with H. pylori eradication, similar to patients without t(11;18) translocation or extra copies of MALT1.<br />Competing Interests: Conflict-of-interest statement: All of the authors declare that they have no conflicts of interest associated with this article.
- Subjects :
- Aged
Aneuploidy
Chromosomes, Human, Pair 11 genetics
Chromosomes, Human, Pair 18 genetics
Disease-Free Survival
Female
Gastric Mucosa microbiology
Gastric Mucosa pathology
Gastric Mucosa radiation effects
Helicobacter Infections microbiology
Helicobacter pylori isolation & purification
Humans
In Situ Hybridization, Fluorescence
Lymphoma, B-Cell, Marginal Zone genetics
Lymphoma, B-Cell, Marginal Zone microbiology
Lymphoma, B-Cell, Marginal Zone mortality
Male
Middle Aged
Oncogene Proteins, Fusion genetics
Radiotherapy methods
Retrospective Studies
Sex Factors
Stomach Neoplasms genetics
Stomach Neoplasms microbiology
Stomach Neoplasms mortality
Translocation, Genetic
Treatment Outcome
Anti-Bacterial Agents therapeutic use
Antineoplastic Agents therapeutic use
Helicobacter Infections drug therapy
Helicobacter pylori drug effects
Lymphoma, B-Cell, Marginal Zone therapy
Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein genetics
Stomach Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 23
- Issue :
- 33
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 28970731
- Full Text :
- https://doi.org/10.3748/wjg.v23.i33.6155