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Determinants of quality of life in Paget's disease of bone.

Authors :: Werner de Castro GR
Castro SAF
Pereira IA
Zimmermann AF
Toscano MA
Neves FS
Scottini MA
Paupitz J
Rosa JSD
Buss Z
Fröde TS
Source :: Revista brasileira de reumatologia [Rev Bras Reumatol Engl Ed] 2017 Nov - Dec; Vol. 57 (6), pp. 566-573. Date of Electronic Publication: 2017 Sep 28.
Publication Year :: 2017
Abstract: Objective: To evaluate the parameters associated with quality of life in patients with Paget's disease of bone.<br />Methods: Patients with Paget's disease of bone were evaluated with SF-36 and WHOQOL-bref questionnaires. Patients with other diseases that could cause significant impairment of their quality of life were excluded. We searched for correlations between the results and: age, time from diagnosis, type of involvement, pain related to Paget's disease of bone, limitation to daily activities, deformities, bone specific alkaline phosphatase, the extent of involvement and treatment.<br />Results: Fifty patients were included. Results of the SF-36 total score and its domains, physical and mental health, were significantly correlated with bone pain and deformities. Marital status was significantly correlated with the SF-36 total score and Mental Health Domain. BAP levels and disease extension were significantly correlated to SF-36 Physical Health Domain. After multivariate analysis, the only parameters that remained significantly associated with the SF-36 total score and to its Mental Health and Physical Health Domains were pain and marital status. The WHOQOL-bref total score was significantly associated with pain, physical impairment and deformities. WHOQOL-bref Domain 1 (physical) score was significantly associated with marital status, pain and deformities, while Domain 2 (psychological) score was associated with marital status, physical impairment and kind of involvement. After multivariate analysis, the presence of pain, deformities, and marital status were significantly associated with results of the WHOQOL-bref total score and its Domain 1. WHOQOL-bref domain 2 results were significantly predicted by pain and marital status.<br />Conclusion: The main disease-related factor associated with SF-36 results in Paget's disease of bone patients was bone pain, while bone pain and deformities were associated with WHOQOL-bref.<br /> (Copyright © 2017 Elsevier Editora Ltda. All rights reserved.)