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Effects of estrogen receptor modulators on cytoskeletal proteins in the central nervous system.
- Source :
-
Neural regeneration research [Neural Regen Res] 2017 Aug; Vol. 12 (8), pp. 1231-1240. - Publication Year :
- 2017
-
Abstract
- Estrogen receptor modulators are compounds of interest because of their estrogenic agonistic/antagonistic effects and tissue specificity. These compounds have many clinical applications, particularly for breast cancer treatment and osteoporosis in postmenopausal women, as well as for the treatment of climacteric symptoms. Similar to estrogens, neuroprotective effects of estrogen receptor modulators have been described in different models. However, the mechanisms of action of these compounds in the central nervous system have not been fully described. We conducted a systematic search to investigate the effects of estrogen receptor modulators in the central nervous system, focusing on the modulation of cytoskeletal proteins. We found that raloxifene, tamoxifen, and tibolone modulate some cytoskeletal proteins such as tau, microtuble-associated protein 1 (MAP1), MAP2, neurofilament 38 (NF38) by different mechanisms of action and at different levels: neuronal microfilaments, intermediate filaments, and microtubule-associated proteins. Finally, we emphasize the importance of the study of these compounds in the treatment of neurodegenerative diseases since they present the benefits of estrogens without their side effects.<br />Competing Interests: Conflicts of interest: None declared.
Details
- Language :
- English
- ISSN :
- 1673-5374
- Volume :
- 12
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Neural regeneration research
- Publication Type :
- Academic Journal
- Accession number :
- 28966632
- Full Text :
- https://doi.org/10.4103/1673-5374.213536