Back to Search
Start Over
Dried blood spots: An evaluation of utility in the field.
- Source :
-
Journal of infection and public health [J Infect Public Health] 2018 May - Jun; Vol. 11 (3), pp. 373-376. Date of Electronic Publication: 2017 Sep 28. - Publication Year :
- 2018
-
Abstract
- Background: Use of dried blood spots (DBS) offers advantages over serum samples in studies conducted in resource-poor settings. The aim of this study was to compare the number of adequate spots collected across different demographic groups.<br />Methods: Five DBS were collected from 3316 individuals aged 0-49 years in Tianjin, China for a measles antibody study; DBS were rated "adequate" or "inadequate." Linear regression, with the number of adequate DBS on a card as the outcome variable, was used to test for predictors of DBS adequacy.<br />Results: There were 0 adequate DBS for 23% of participants and 5 adequate DBS for 24%. Mean number of adequate DBS was 1.68 in infants (<12 months), 2.57 (1-9 years), 3.49 (10-29 years), 3.08 (30-49 years). The number of adequate DBS increased over the study; the mean number of adequate DBS for the five years 2011-2015 were 1.21, 2.52, 3.40, 2.22, and 3.62, respectively. DBS quality was not related to measles IgG antibodies.<br />Conclusions: DBS are an alternative for adults and children but pose challenges in infants, and improve with experience. In a resource-limited environment or in a scenario where more invasive techniques like venipuncture may be less accepted by the study population, DBS can be the preferred technique to efficiently obtain serum specimens for analyte testing.<br /> (Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1876-035X
- Volume :
- 11
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of infection and public health
- Publication Type :
- Academic Journal
- Accession number :
- 28965796
- Full Text :
- https://doi.org/10.1016/j.jiph.2017.09.014