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Origins and consequences of congenital heart defects affecting the right ventricle.
- Source :
-
Cardiovascular research [Cardiovasc Res] 2017 Oct 01; Vol. 113 (12), pp. 1509-1520. - Publication Year :
- 2017
-
Abstract
- Congenital heart disease is a major health issue, accounting for a third of all congenital defects. Improved early surgical management has led to a growing population of adults with congenital heart disease, including patients with defects affecting the right ventricle, which are often classified as severe. Defects affecting the right ventricle often cause right ventricular volume or pressure overload and affected patients are at high risk for complications such as heart failure and sudden death. Recent insights into the developmental mechanisms and distinct developmental origins of the left ventricle, right ventricle, and the outflow tract have shed light on the common features and distinct problems arising in specific defects. Here, we provide a comprehensive overview of the current knowledge on the development into the normal and congenitally malformed right heart and the clinical consequences of several congenital heart defects affecting the right ventricle.<br /> (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2017. For permissions, please email: journals.permissions@oup.com.)
- Subjects :
- Animals
Gene Expression Regulation, Developmental
Heart Defects, Congenital diagnostic imaging
Heart Defects, Congenital genetics
Heart Defects, Congenital physiopathology
Heart Ventricles diagnostic imaging
Heart Ventricles physiopathology
Humans
Hypertrophy, Right Ventricular diagnostic imaging
Hypertrophy, Right Ventricular genetics
Hypertrophy, Right Ventricular physiopathology
Morphogenesis
Risk Factors
Ventricular Dysfunction, Right diagnostic imaging
Ventricular Dysfunction, Right genetics
Ventricular Dysfunction, Right physiopathology
Ventricular Remodeling
Heart Defects, Congenital complications
Heart Ventricles abnormalities
Hypertrophy, Right Ventricular etiology
Ventricular Dysfunction, Right etiology
Ventricular Function, Right
Subjects
Details
- Language :
- English
- ISSN :
- 1755-3245
- Volume :
- 113
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Cardiovascular research
- Publication Type :
- Academic Journal
- Accession number :
- 28957538
- Full Text :
- https://doi.org/10.1093/cvr/cvx155