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Role of cardiac inflammation in right ventricular failure.
- Source :
-
Cardiovascular research [Cardiovasc Res] 2017 Oct 01; Vol. 113 (12), pp. 1441-1452. - Publication Year :
- 2017
-
Abstract
- Right ventricular failure (RVF) is the main determinant of mortality in patients with pulmonary arterial hypertension (PAH). Although the exact pathophysiology underlying RVF remains unclear, inflammation may play an important role, as it does in left heart failure. Perivascular pulmonary artery and systemic inflammation is relatively well studied and known to contribute to the initiation and maintenance of the pulmonary vascular insult in PAH. However, less attention has been paid to the role of cardiac inflammation in RVF and PAH. Consistent with many other types of heart failure, cardiac inflammation, triggered by systemic and local stressors, has been shown in RVF patients as well as in RVF animal models. RV inflammation likely contributes to impaired RV contractility, maladaptive remodelling and a vicious circle between RV and pulmonary vascular injury. Although the potential to improve RV function through anti-inflammatory therapy has not been tested, this approach has been applied clinically in left ventricular failure patients, with variable success. Because inflammation plays a dual role in the development of both pulmonary vascular pathology and RVF, anti-inflammatory therapies may have a potential double benefit in patients with PAH and associated RVF.<br /> (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2017. For permissions, please email: journals.permissions@oup.com.)
- Subjects :
- Animals
Anti-Infective Agents therapeutic use
Apoptosis
Arterial Pressure
Cytokines metabolism
Fibrosis
Heart Failure drug therapy
Heart Failure metabolism
Heart Failure physiopathology
Humans
Hypertension, Pulmonary metabolism
Hypertension, Pulmonary physiopathology
Inflammation Mediators metabolism
Myocarditis drug therapy
Myocarditis metabolism
Myocarditis physiopathology
Pulmonary Artery physiopathology
Risk Factors
Ventricular Dysfunction, Right drug therapy
Ventricular Dysfunction, Right metabolism
Ventricular Dysfunction, Right physiopathology
Ventricular Remodeling
Heart Failure etiology
Hypertension, Pulmonary complications
Myocarditis complications
Ventricular Dysfunction, Right etiology
Ventricular Function, Right drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1755-3245
- Volume :
- 113
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Cardiovascular research
- Publication Type :
- Academic Journal
- Accession number :
- 28957536
- Full Text :
- https://doi.org/10.1093/cvr/cvx159