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Poly(Lactic Acid) Blends with Poly(Trimethylene Carbonate) as Biodegradable Medical Adhesive Material.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2017 Sep 28; Vol. 18 (10). Date of Electronic Publication: 2017 Sep 28. - Publication Year :
- 2017
-
Abstract
- A novel medical adhesive was prepared by blending poly(lactic acid) (PLA) with poly(trimethylene carbonate) (PTMC) in ethyl acetate, and the two materials were proven to be biodegradable and biocompatible. The medical adhesive was characterized by ¹H nuclear magnetic resonance (¹HNMR), gel permeation chromatography (GPC), scanning electron microscopy (SEM) and differential scanning calorimetry (DSC). The water vapor transmission rate (WVTR) of this material was measured to be 7.13 g·cm <superscript>-2</superscript> ·24 h <superscript>-1</superscript> . Its degree of comfortability was confirmed by the extensibility (E) and the permanent set (PS), which were approximately 7.83 N·cm <superscript>-2</superscript> and 18.83%, respectively. In vivo tests regarding rabbit immunoglobulin M (IgM), rabbit immunoglobulin G (IgG), rabbit bone alkaline phosphatase (BALP), rabbit interleukin 6 (IL-6), rabbit interleukin 10 (IL-10), rabbit tumor necrosis factor α(TNFα), glutamic-oxaloacetic transaminase (AST/GOT), glutamic-pyruvic transaminase (ALT/GPT), alkaline phosphatase (AKP), blood urea nitrogen (BUN) and creatinine (Cr) indicated that the PLA-PTMC medical adhesive was not harmful to the liver and kidneys. Finally, pathological sections indicated that PLA-PTMC was more effective than the control group. These data suggest that in addition to having a positive effect on hemostasis and no sensibility to wounds, PLA-PTMC can efficiently prevent infections and has great potential as a medical adhesive.<br />Competing Interests: The authors declare no conflict of interest.
- Subjects :
- Animals
Calorimetry, Differential Scanning
Cell Survival
Female
Male
Materials Testing
Microscopy, Electron, Scanning
Proton Magnetic Resonance Spectroscopy
Rabbits
Skin pathology
Wound Healing
Adhesives
Biocompatible Materials chemistry
Dioxanes chemistry
Polyesters chemistry
Polymers chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 18
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 28956808
- Full Text :
- https://doi.org/10.3390/ijms18102041