Phenolic extracts and amino acids content from Cucumeropsis mannii naudin and Citrullus lanatus inhibit relevant enzymes of erectile dysfunction in rat's penile tissue.

•A focused on the erectogenic potentials of two tropical pumpkin seeds was established.•The antioxidant properties of these seed varieties were also discussed.•The inhibitory effects of the seeds on key enzymes relevant to ED were critically explored.•The potentials of the seeds to manage ED were recommended.