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Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2017 Nov 01; Vol. 199 (9), pp. 3261-3269. Date of Electronic Publication: 2017 Sep 27. - Publication Year :
- 2017
-
Abstract
- TLR signaling is critical to innate immune system regulation; however, aberrant TLR signaling is involved in several diseases, including insulin resistance, Alzheimer's disease, and tumor metastasis. Moreover, a recent study found that TLR-4 signaling pathway inhibition might be a target for the suppression of chronic inflammatory disorders. In this article, we show that the green tea polyphenol epigallocatechin-3- O -gallate (EGCG) increases the expression of Toll interacting protein, a strong inhibitor of TLR4 signaling, by suppressing the expression of E74-like ETS transcription factor 1 (Elf-1). A mechanistic study revealed that EGCG suppressed Elf-1 expression via protein phosphatase 2A/cyclic GMP (cGMP)-dependent mechanisms. We also confirmed that orally administered EGCG and a cGMP inducer upregulated Toll interacting protein expression, increased intracellular levels of cGMP in macrophages, and suppressed Elf-1 expression. These data support EGCG and a cGMP inducer as potential candidate suppressors of TLR4 signaling.<br /> (Copyright © 2017 by The American Association of Immunologists, Inc.)
- Subjects :
- Animals
Catechin chemistry
Catechin pharmacology
Cyclic GMP genetics
Cyclic GMP immunology
DNA-Binding Proteins genetics
Intracellular Signaling Peptides and Proteins genetics
Male
Mice
Mice, Inbred BALB C
Nuclear Proteins genetics
Protein Phosphatase 2 genetics
Protein Phosphatase 2 immunology
Second Messenger Systems genetics
Toll-Like Receptor 4 genetics
Toll-Like Receptor 4 immunology
Transcription Factors genetics
Catechin analogs & derivatives
DNA-Binding Proteins immunology
Intracellular Signaling Peptides and Proteins immunology
Nuclear Proteins immunology
Second Messenger Systems immunology
Tea chemistry
Transcription Factors immunology
Up-Regulation immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1550-6606
- Volume :
- 199
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 28954885
- Full Text :
- https://doi.org/10.4049/jimmunol.1601822