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What semantic dementia teaches us about the functional organization of the left posterior fusiform gyrus.
- Source :
-
Neuropsychologia [Neuropsychologia] 2017 Nov; Vol. 106, pp. 159-168. Date of Electronic Publication: 2017 Sep 23. - Publication Year :
- 2017
-
Abstract
- After demonstrating the relative preservation of fruit and vegetable knowledge in patients with semantic dementia (SD), we sought to identify the neural substrate of this unusual category effect. Nineteen patients with SD performed a semantic sorting task and underwent a morphometric 3T MRI scan. The grey-matter volumes of five regions within the temporal lobe were bilaterally computed, as well as those of two recently described areas (FG1 and FG2) within the posterior fusiform gyrus. In contrast to the other semantic categories we tested, fruit and vegetable scores were only predicted by left FG1 volume. We therefore found a specific relationship between the volume of a subregion within the left posterior fusiform gyrus and performance on fruits and vegetables in SD. We argue that the left FG1 is a convergence zone for the features that might be critical to successfully sort fruits and vegetables. We also discuss evidence for a functional specialization of the fusiform gyrus along two axes (lateral medial and longitudinal), depending on the nature of the concepts and on the level of processing complexity required by the ongoing task.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Analysis of Variance
Case-Control Studies
Cognition Disorders etiology
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Mental Status Schedule
Middle Aged
Neuropsychological Tests
Photic Stimulation
Brain Mapping
Frontotemporal Dementia diagnostic imaging
Frontotemporal Dementia physiopathology
Functional Laterality physiology
Temporal Lobe diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3514
- Volume :
- 106
- Database :
- MEDLINE
- Journal :
- Neuropsychologia
- Publication Type :
- Academic Journal
- Accession number :
- 28951166
- Full Text :
- https://doi.org/10.1016/j.neuropsychologia.2017.09.023