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The IL-4 rs2070874 polymorphism may be associated with the severity of recurrent viral-induced wheeze.

Authors :
Amat F
Louha M
Benet M
Guiddir T
Bourgoin-Heck M
Saint-Pierre P
Paluel-Marmont C
Fontaine C
Lambert N
Couderc R
Gonzalez JR
Just J
Source :
Pediatric pulmonology [Pediatr Pulmonol] 2017 Nov; Vol. 52 (11), pp. 1435-1442. Date of Electronic Publication: 2017 Sep 26.
Publication Year :
2017

Abstract

Background: Childhood recurrent wheezing and consequently asthma corresponds to various phenotypes. Our aim was to link genetic variants of asthma candidate genes to the phenotypes of early onset wheezing.<br />Study Design: We included very young consecutive children presenting with recurrent wheezing who had been evaluated for the severity of wheezing, associated atopic comorbidities, and tested for biomarkers of atopy and inflammation. All were genotyped for 16 single nucleotide polymorphisms (SNPs) linked with asthma or atopy. An unsupervised hierarchical bottom-up method was used for clustering the phenotypes and a multinomial logistic regression was performed for each individual SNP.<br />Results: We replicated the three phenotypes previously described Trousseau Asthma Program in 317 children aged 21.5 ± 7.9 months: cluster 1 (nonatopic uncontrolled severe wheeze), n = 207, a severe viral-induced wheeze, cluster 2 (atopic multiple trigger wheeze), n = 61, with multiple allergic comorbidities, and cluster 3 (episodic viral wheeze), n = 49, a mild viral-induced wheeze. The TT-genotype of the IL-4 rs2070874 polymorphism was significantly associated with the nonatopic uncontrolled severe wheeze compared to the episodic viral wheeze (OR 7.9; CI95% [2.5-25.3]; P = 0.001).<br />Conclusion: Association between the TT-genotype of IL-4 rs2070874 polymorphism and a severe phenotype of viral-induced wheeze further underlines the role IL-4 plays in the inflammation pathway leading to viral respiratory infections.<br /> (© 2017 Wiley Periodicals, Inc.)

Details

Language :
English
ISSN :
1099-0496
Volume :
52
Issue :
11
Database :
MEDLINE
Journal :
Pediatric pulmonology
Publication Type :
Academic Journal
Accession number :
28950434
Full Text :
https://doi.org/10.1002/ppul.23834