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Novel interactors of the Drosophila Survival Motor Neuron (SMN) Complex suggest its full conservation.
- Source :
-
FEBS letters [FEBS Lett] 2017 Nov; Vol. 591 (21), pp. 3600-3614. Date of Electronic Publication: 2017 Oct 10. - Publication Year :
- 2017
-
Abstract
- The Spinal Muscular Atrophy disease protein Survival Motor Neuron (SMN) operates as part of a multiprotein complex whose components also include Gemins 2-8 and Unrip. The fruit fly Drosophila melanogaster is thought to have a slightly smaller SMN complex comprised of SMN, Gemin2/3/5 and, possibly, Unrip. Based upon in vivo interaction methods, we have identified novel interacting partners of the Drosophila SMN complex with homologies to Gemin4/6/7/8. The Gemin4 and Gemin8 orthologues are required for neuromuscular function and survival. The Gemin6/7/Unrip module can be recruited via the SMN-associated Gemin8, hence mirroring the human SMN complex architecture. Our findings lead us to propose that an elaborate SMN complex that is typical in metazoans is also present in Drosophila.<br /> (© 2017 Federation of European Biochemical Societies.)
Details
- Language :
- English
- ISSN :
- 1873-3468
- Volume :
- 591
- Issue :
- 21
- Database :
- MEDLINE
- Journal :
- FEBS letters
- Publication Type :
- Report
- Accession number :
- 28949413
- Full Text :
- https://doi.org/10.1002/1873-3468.12853