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Novel synthetic drugs currently in clinical development for chronic lymphocytic leukemia.
- Source :
-
Expert opinion on investigational drugs [Expert Opin Investig Drugs] 2017 Nov; Vol. 26 (11), pp. 1249-1265. Date of Electronic Publication: 2017 Oct 03. - Publication Year :
- 2017
-
Abstract
- Introduction: Over the last few years, several new synthetic drugs, particularly Bruton's tyrosine kinase (BTK), phosphatidylinositol 3-kinase (PI3K) and BCL-2 inhibitors have been developed and investigated in chronic lymphocytic leukemia (CLL). Areas covered: This review highlights key aspects of BTK, PI3K and BCL-2 inhibitors that are currently at various stages of preclinical and clinical development in CLL. A literature review of the MEDLINE database for articles in English concerning CLL, B-cell receptor, BCL-2 antagonists, BTK inhibitors and PI3K inhibitors, was conducted via PubMed. Publications from 2000 through July 2017 were scrutinized. The search terms used were acalabrutinib, ACP-196, BGB-3111, ONO-4059, GS-4059, duvelisib, IPI-145, TGR-1202, copanlisib, Bay 80-6946, buparlisib, BKM-120, BCL-2 inhibitors, venetoclax, ABT-263, navitoclax, CDK inhibitors, alvocidib, flavopiridol, dinaciclib, SCH 727,965, palbociclib, PD-0332991, in conjunction with CLL. Conference proceedings from the previous five years of the ASH and EHA Annual Scientific Meetings were searched manually. Additional relevant publications were obtained by reviewing the references from the chosen articles. Expert opinion: The use of new synthetic drugs is a promising strategy for the treatment of CLL. Data from ongoing and future clinical trials will aid in better defining the status of new drugs in the treatment of CLL.
- Subjects :
- Animals
Antineoplastic Agents pharmacology
Drugs, Investigational pharmacology
Drugs, Investigational therapeutic use
Humans
Leukemia, Lymphocytic, Chronic, B-Cell pathology
Molecular Targeted Therapy
Antineoplastic Agents therapeutic use
Drug Design
Leukemia, Lymphocytic, Chronic, B-Cell drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1744-7658
- Volume :
- 26
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Expert opinion on investigational drugs
- Publication Type :
- Academic Journal
- Accession number :
- 28942659
- Full Text :
- https://doi.org/10.1080/13543784.2017.1384814