Back to Search
Start Over
Validation of GEMCaP as a DNA Based Biomarker to Predict Prostate Cancer Recurrence after Radical Prostatectomy.
- Source :
-
The Journal of urology [J Urol] 2018 Mar; Vol. 199 (3), pp. 719-725. Date of Electronic Publication: 2017 Sep 20. - Publication Year :
- 2018
-
Abstract
- Purpose: We aimed to validate GEMCaP (Genomic Evaluators of Metastatic Cancer of the Prostate) as a novel copy number signature predictive of prostate cancer recurrence.<br />Materials and Methods: We randomly selected patients who underwent radical prostatectomy at Cleveland Clinic or University of Rochester from 2000 to 2005. DNA isolated from the cancer region was extracted and subjected to high resolution array comparative genomic hybridization. A high GEMCaP score was defined as 20% or greater of genomic loci showing copy number gain or loss in a given tumor. Cox regression was used to evaluate associations between the GEMCaP score and the risk of biochemical recurrence.<br />Results: We report results in 140 patients. Overall 38% of patients experienced recurrence with a median time to recurrence of 45 months. Based on the CAPRA-S (Cancer of the Prostate Risk Assessment Post-Surgical) score 39% of the patients were at low risk, 42% were at intermediate risk and 19% were at high risk. The GEMCaP score was high (20% or greater) in 31% of the cohort. A high GEMCaP score was associated with a higher risk of biochemical recurrence (HR 2.69, 95% CI 1.51-4.77) and it remained associated after adjusting for CAPRA-S score and age (HR 1.94, 95% CI 1.06-3.56). The C-index of GEMCaP alone was 0.64, which improved when combined with the CAPRA-S score and patient age (C-index = 0.75).<br />Conclusions: A high GEMCaP score was associated with biochemical recurrence in 2 external cohorts. This remained true after adjusting for clinical and pathological factors. The GEMCaP biomarker could be an efficient and effective clinical risk assessment tool to identify patients with prostate cancer for early adjuvant therapy.<br /> (Copyright © 2018 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Biomarkers, Tumor blood
Comparative Genomic Hybridization
Follow-Up Studies
Humans
Male
Middle Aged
Neoplasm Recurrence, Local genetics
Neoplasm Recurrence, Local metabolism
Predictive Value of Tests
Prognosis
Prostate-Specific Antigen blood
Prostatic Neoplasms metabolism
Prostatic Neoplasms surgery
Retrospective Studies
Risk Assessment
DNA, Neoplasm genetics
Neoplasm Recurrence, Local diagnosis
Prostate pathology
Prostatectomy methods
Prostatic Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1527-3792
- Volume :
- 199
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of urology
- Publication Type :
- Academic Journal
- Accession number :
- 28941923
- Full Text :
- https://doi.org/10.1016/j.juro.2017.09.071