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Microwave-Assisted Rapid One-Pot Synthesis of Fused and Non-Fused Indoles and 5-[ 18 F]Fluoroindoles from Phenylazocarboxylates.
- Source :
-
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2017 Nov 16; Vol. 23 (64), pp. 16174-16178. Date of Electronic Publication: 2017 Oct 23. - Publication Year :
- 2017
-
Abstract
- Substituted indoles can be prepared from phenylazocarboxylates through a rapid one-pot sequence featuring a microwave-assisted Fischer indole synthesis as a key step. Considering that the phenylazocarboxylates may beforehand be modified by mild nucleophilic aromatic substitution, including the introduction of [ <superscript>18</superscript> F]fluoride, the overall strategy offers an attractive new access to 5-[ <superscript>18</superscript> F]fluoroindoles.<br /> (© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Details
- Language :
- English
- ISSN :
- 1521-3765
- Volume :
- 23
- Issue :
- 64
- Database :
- MEDLINE
- Journal :
- Chemistry (Weinheim an der Bergstrasse, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 28940808
- Full Text :
- https://doi.org/10.1002/chem.201703890