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[18F] FDOPA standardized uptake values of brain tumors are not exclusively dependent on LAT1 expression.
- Source :
-
PloS one [PLoS One] 2017 Sep 22; Vol. 12 (9), pp. e0184625. Date of Electronic Publication: 2017 Sep 22 (Print Publication: 2017). - Publication Year :
- 2017
-
Abstract
- [18F]-FDOPA is a labeled amino acid (AA) analog used for positron emission tomography (PET) which is gaining increasing interest in the evaluation of brain tumors (BT). The AA-transporter LAT1 has been shown to be involved in [18F]-FDOPA uptake. The aim of this study was to determine whether the [18F]-FDOPA uptake was correlated with level of LAT1 expression in BT. Twenty-eight BT (including 19 gliomas and 9 metastases) were investigated by [18F]-FDOPA-PET prior to surgery and by anti-LAT1 immunohistochemistry on surgical specimens. The quantitative [18F]-FDOPA measured parameters were SUVmax, SUVmean and SUVpeak. LAT1 expression was quantified using a score (0 to 400). A significant [18F]-FDOPA uptake was associated with a LAT1 score ≥ 100 (p = 0.02) but there was no linear correlation between intensity of [18F]-FDOPA uptake and score of LAT1 expression whatever the parameters considered. LAT1 expression alone is not sufficient to explain variation of intensity of [18F]-FDOPA uptake in BT.
- Subjects :
- Adult
Aged
Brain diagnostic imaging
Brain metabolism
Brain pathology
Brain surgery
Brain Neoplasms diagnostic imaging
Brain Neoplasms pathology
Brain Neoplasms surgery
Female
Glioma diagnostic imaging
Glioma metabolism
Glioma pathology
Glioma surgery
Humans
Immunohistochemistry
Male
Middle Aged
Amino Acid Transport Systems, Basic metabolism
Brain Neoplasms metabolism
Dihydroxyphenylalanine pharmacokinetics
Fluorine Radioisotopes pharmacokinetics
Positron-Emission Tomography
Radiopharmaceuticals pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 12
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 28937983
- Full Text :
- https://doi.org/10.1371/journal.pone.0184625