Anti-inflammatory approaches to ischaemic stroke prevention.

Stroke is a major cause of neurological morbidity and mortality. Atherosclerosis is a major contributor to first and recurrent stroke. A growing evidence base indicates that inflammation is a key process in the pathogenesis of atherosclerosis, leading to thromboembolic events. In this review, we summarise the evidence linking inflammation to stroke risk and discuss clinical trials addressing the 'inflammation hypothesis' in coronary disease and stroke. Trial registration number CONVINCE trial ClinicalTrials.gov number; NCT 02898610; Pre-results.
Competing Interests: Competing interests: PJK is chief investigator of the CONVINCE (COlchicine for preventioN of Vascular Inflammation in Non-Cardio-Embolic stroke) trial funded by the Health Research Board of Ireland. SM, FP, RL, GT and CP are national lead investigators for CONVINCE in their respective countries and serve on the trial steering committee.
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