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Genome-wide association study evaluating single-nucleotide polymorphisms and outcomes in patients with advanced stage serous ovarian or primary peritoneal cancer: An NRG Oncology/Gynecologic Oncology Group study.
- Source :
-
Gynecologic oncology [Gynecol Oncol] 2017 Nov; Vol. 147 (2), pp. 396-401. Date of Electronic Publication: 2017 Sep 19. - Publication Year :
- 2017
-
Abstract
- Objective: This study evaluated single nucleotide polymorphisms (SNPs) associated with progression free (PFS) and overall survival (OS) in patients with advanced stage serous EOC.<br />Methods: Patients enrolled in GOG-172 and 182 who provided specimens for translational research and consent were included. Germline DNA was evaluated with the Illumina's HumanOMNI1-Quad beadchips and scanned using Illumina's iScan optical imaging system. SNPs with allele frequency>0.05 and genotyping rate>0.98 were included. Analysis of SNPs for PFS and OS was done using Cox regression. Statistical significance was determined using Bonferroni corrected p-values with genomic control adjustment.<br />Results: The initial GWAS analysis included 1,124,677 markers in 396 patients. To obtain the final data set, quality control checks were performed and limited to serous tumors and self-identified Caucasian race. In total 636,555 SNPs and 289 patients passed all the filters. The pre-specified statistical level of significance was 7.855e <superscript>-08</superscript> . No SNPs met this criteria for PFS or OS, however, two SNPs were close to significance (rs10899426 p-2.144e <superscript>-</superscript> <superscript>08</superscript> ) (rs6256 p-9.774e <superscript>-07</superscript> ) for PFS and 2 different SNPs were identified (rs295315 p-7.536e <superscript>-</superscript> <superscript>07</superscript> ; rs17693104 p-7.734e <superscript>-</superscript> <superscript>07</superscript> ) which were close to significance for OS.<br />Conclusions: Using the pre-specified level of significance of 1×10 <superscript>-08</superscript> , we did not identify any SNPs of statistical significance for OS or PFS, however several were close. The SNP's identified in this GWAS study will require validation and these preliminary findings may lead to identification of novel pathways and biomarkers.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols administration & dosage
Cystadenocarcinoma, Serous drug therapy
Cystadenocarcinoma, Serous pathology
Female
Genome-Wide Association Study
Humans
Middle Aged
Neoplasm Staging
Ovarian Neoplasms drug therapy
Ovarian Neoplasms pathology
Peritoneal Neoplasms drug therapy
Peritoneal Neoplasms pathology
Polymorphism, Single Nucleotide
Prognosis
Randomized Controlled Trials as Topic
Cystadenocarcinoma, Serous genetics
Ovarian Neoplasms genetics
Peritoneal Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1095-6859
- Volume :
- 147
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Gynecologic oncology
- Publication Type :
- Academic Journal
- Accession number :
- 28935272
- Full Text :
- https://doi.org/10.1016/j.ygyno.2017.08.024