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Conflicting interactions of apolipoprotein A and high density lipoprotein cholesterol with microvascular complications of type 2 diabetes.
- Source :
-
Diabetes research and clinical practice [Diabetes Res Clin Pract] 2017 Nov; Vol. 133, pp. 131-141. Date of Electronic Publication: 2017 Sep 01. - Publication Year :
- 2017
-
Abstract
- Aims: This study is amid at investigating the associations, and interactions of serum lipid biomarkers with microvascular complications of type 2 diabetes (T2D).<br />Methods: A nested case-control study was conducted within an ongoing prospective study on patients with T2D. Microvascular complications of T2D including diabetic neuropathy, diabetic retinopathy and diabetic nephropathy were investigated. A total of 444 cases with at least one of the microvascular complications of T2D and 439 age- and gender-matched controls free of any of the chronic microvascular complications of T2D were included. The associations and interactions of a panel of serum lipid biomarkers with the microvascular complications of T2D were investigated.<br />Results: Serum triglyceride had the strongest association with microvascular complications of T2D (crude model: β=0.632, P value=0.045). Each standard deviation increment in serum TG was associated with 3.7 times increased frequency of microvascular complications. Despite high density lipoprotein cholesterol (HDL-C), serum apolipoprotein A1 (Apo A1) was positively associated with the presence of diabetic neuropathy. Each standard deviation increment in serum ApoA1 was associated with increased frequency of diabetic neuropathy (OR, 1.2, 95% CI, (1.1-1.3), P value=0.006). The frequency of diabetic neuropathy was higher in 2nd and 3rd quartiles of serum Lp(a) compared to diabetic patients in the first quartile (OR, 5.52, 95% (1.17-25.8), P value=0.047).<br />Conclusions: ApoA1 but not HDL-C is straightly associated with diabetic neuropathy. Even Slight rise in serum Lp(a) is associated with increased frequency of diabetic retinopathLipid variables could serve as specific predictors of vascular complications in diabetes.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Subjects :
- Aged
Biomarkers blood
Cardiovascular Diseases etiology
Case-Control Studies
Diabetes Mellitus, Type 2 complications
Diabetic Neuropathies etiology
Female
Humans
Lipids blood
Male
Middle Aged
Prospective Studies
Apolipoprotein A-I blood
Cardiovascular Diseases blood
Cholesterol, HDL blood
Diabetes Mellitus, Type 2 blood
Diabetic Neuropathies blood
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8227
- Volume :
- 133
- Database :
- MEDLINE
- Journal :
- Diabetes research and clinical practice
- Publication Type :
- Academic Journal
- Accession number :
- 28934670
- Full Text :
- https://doi.org/10.1016/j.diabres.2017.07.037