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A Recombinant Measles Vaccine with Enhanced Resistance to Passive Immunity.
- Source :
-
Viruses [Viruses] 2017 Sep 21; Vol. 9 (10). Date of Electronic Publication: 2017 Sep 21. - Publication Year :
- 2017
-
Abstract
- Current measles vaccines suffer from poor effectiveness in young infants due primarily to the inhibitory effect of residual maternal immunity on vaccine responses. The development of a measles vaccine that resists such passive immunity would strongly contribute to the stalled effort toward measles eradication. In this concise communication, we show that a measles virus (MV) with enhanced hemagglutinin (H) expression and incorporation, termed MVvac2-H2, retained its enhanced immunogenicity, previously established in older mice, when administered to very young, genetically modified, MV-susceptible mice in the presence of passive anti-measles immunity. This immunity level mimics the sub-neutralizing immunity prevalent in infants too young to be vaccinated. Additionally, toward a more physiological small animal model of maternal anti-measles immunity interference, we document vertical transfer of passive anti-MV immunity in genetically-modified, MV susceptible mice and show in this physiological model a better MVvac2-H2 immunogenic profile than that of the parental vaccine strain. In sum, these data support the notion that enhancing MV hemagglutinin incorporation can circumvent in vivo neutralization. This strategy merits additional exploration as an alternative pediatric measles vaccine.<br />Competing Interests: The authors declare no conflict of interest.
- Subjects :
- Age Factors
Animals
Antibodies, Viral blood
Antibodies, Viral immunology
Chlorocebus aethiops
Hemagglutinins, Viral genetics
Humans
Immune Sera immunology
Immunologic Factors immunology
Infant
Measles Vaccine genetics
Mice
Models, Animal
Vaccination
Vaccines, Synthetic genetics
Vaccines, Synthetic immunology
Vero Cells
Hemagglutinins, Viral immunology
Immunity, Maternally-Acquired immunology
Immunogenicity, Vaccine immunology
Measles prevention & control
Measles Vaccine immunology
Measles virus immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1999-4915
- Volume :
- 9
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Viruses
- Publication Type :
- Academic Journal
- Accession number :
- 28934110
- Full Text :
- https://doi.org/10.3390/v9100265