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Relatedness of wildlife and livestock avian isolates of the nosocomial pathogen Acinetobacter baumannii to lineages spread in hospitals worldwide.
- Source :
-
Environmental microbiology [Environ Microbiol] 2017 Oct; Vol. 19 (10), pp. 4349-4364. Date of Electronic Publication: 2017 Oct 09. - Publication Year :
- 2017
-
Abstract
- The natural habitats and potential reservoirs of the nosocomial pathogen Acinetobacter baumannii are poorly defined. Here, we put forth and tested the hypothesis of avian reservoirs of A. baumannii. We screened tracheal and rectal swab samples from livestock (chicken, geese) and wild birds (white stork nestlings) and isolated A. baumannii from 3% of sampled chicken (n = 220), 8% of geese (n = 40) and 25% of white stork nestlings (n = 661). Virulence of selected avian A. baumannii isolates was comparable to that of clinical isolates in the Galleria mellonella infection model. Whole genome sequencing revealed the close relationship of an antibiotic-susceptible chicken isolate from Germany with a multidrug-resistant human clinical isolate from China and additional linkages between livestock isolates and human clinical isolates related to international clonal lineages. Moreover, we identified stork isolates related to human clinical isolates from the United States. Multilocus sequence typing disclosed further kinship between avian and human isolates. Avian isolates do not form a distinct clade within the phylogeny of A. baumannii, instead they diverge into different lineages. Further, we provide evidence that A. baumannii is constantly present in the habitats occupied by storks. Collectively, our study suggests A. baumannii could be a zoonotic organism that may disseminate into livestock.<br /> (© 2017 The Authors. Environmental Microbiology published by Society for Applied Microbiology and John Wiley & Sons Ltd.)
- Subjects :
- A549 Cells
Acinetobacter baumannii isolation & purification
Animals
Anti-Bacterial Agents
Base Sequence
Cell Line
China
Cross Infection microbiology
Drug Resistance, Multiple, Bacterial genetics
Genome, Bacterial genetics
Germany
Hospitals
Humans
Multilocus Sequence Typing
Phylogeny
Poland
Sequence Analysis, DNA
United States
Whole Genome Sequencing
Acinetobacter Infections microbiology
Acinetobacter baumannii classification
Acinetobacter baumannii genetics
Chickens microbiology
Disease Reservoirs microbiology
Geese microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1462-2920
- Volume :
- 19
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Environmental microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 28925528
- Full Text :
- https://doi.org/10.1111/1462-2920.13931