Synergistic Effects of Tacrolimus and Azoles against Exophiala dermatitidis.

Authors :: Gao L
Sun Y
He C
Zeng T
Li M
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2017 Nov 22; Vol. 61 (12). Date of Electronic Publication: 2017 Nov 22 (Print Publication: 2017).
Publication Year :: 2017
Abstract: In vitro interactions of tacrolimus, a calcineurin inhibitor, and azoles, including itraconazole, voriconazole, and posaconazole, against planktonic cells and biofilms of Exophiala dermatitidis were assessed via a broth microdilution checkerboard technique. A total of 16 clinical isolates were studied. The results revealed favorable synergistic inhibitory activity between tacrolimus and itraconazole, voriconazole, or posaconazole against 68.8%, 87.5%, and 100% of tested strains of planktonic E. dermatitidis , respectively.However, limited synergism was observed against biofilms of E. dermatitidis No antagonism was observed in all combinations.<br /> (Copyright © 2017 American Society for Microbiology.)