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Relationship between glycaemic levels and arterial stiffness in non-diabetic adults.
- Source :
-
Medicina clinica [Med Clin (Barc)] 2018 Jan 23; Vol. 150 (2), pp. 56-60. Date of Electronic Publication: 2017 Sep 18. - Publication Year :
- 2018
-
Abstract
- Objective: To examine, in a non-diabetic population, whether the association between arterial stiffness and glycaemic levels depends on the test used as a glycaemic indicator, fasting plasma glucose (FPG) or glycated haemoglobin A1c (HbA1c).<br />Patient Population and Methods: A cross-sectional analysis of a 220 non-diabetic subsample from the EVIDENT II study in which FPG, HbA1c and arterial stiffness-related parameters (pulse wave velocity, radial and central augmentation index, and central pulse pressure) were determined. Mean differences in arterial stiffness-related parameters by HbA1c and FPG tertiles were tested using analysis of covariance.<br />Results: All means of arterial stiffness-related parameters increased by HbA1c tertiles, although mean differences were only statistically significant in pulse wave velocity (p ≤.001), even after controlling for potential confounders (HbA1c <5.30% = 6.88 m/s; HbA1c 5.30%-5.59% = 7.06 m/s; and HbA1c ≥5.60% = 8.16 m/s, p =.004). Conversely, mean differences in pulse wave velocity by FPG tertiles did not reach statistically significant differences after controlling for potential confounders (FPG 4.44 mmol/l = 7.18 m/s; FPG 4.44 mmol/l-4.87 mmol/l = 7.26 m/s; and FPG ≥4.88 mmol/l = 7.93 m/s, p =.066).<br />Conclusions: Glucose levels in a non-diabetic population were associated with arterial stiffness but better when levels were determined using HbA1c.<br /> (Copyright © 2017 Elsevier España, S.L.U. All rights reserved.)
Details
- Language :
- English; Spanish; Castilian
- ISSN :
- 1578-8989
- Volume :
- 150
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Medicina clinica
- Publication Type :
- Academic Journal
- Accession number :
- 28923672
- Full Text :
- https://doi.org/10.1016/j.medcli.2017.06.072