Back to Search
Start Over
Endocan Serum Levels in Patients with Non-Alcoholic Fatty Liver Disease with or without Type 2 Diabetes Mellitus: A Pilot Study.
- Source :
-
Journal of gastrointestinal and liver diseases : JGLD [J Gastrointestin Liver Dis] 2017 Sep; Vol. 26 (3), pp. 261-268. - Publication Year :
- 2017
-
Abstract
- Background and Aims: Non-alcoholic fatty liver disease (NAFLD) is emerging as an independent cardiovascular risk factor. Recently, Endocan has been studied as an early marker of endothelial dysfunction. Our aim was to evaluate Endocan serum levels in patients with NAFLD with or without type 2 diabetes mellitus.<br />Method: We enrolled 56 patients: 19 with NAFLD and 37 with type 2 diabetes mellitus with or without NAFLD, and compared them to 25 healthy controls. Endocan serum level was measured by using the ELISA EndoMark assay.<br />Results: Endocan level was significantly higher in NAFLD subjects, compared to controls (1.23+/-1.51 vs 0.68+/-0.4 ng/mL; p=0.016). It was higher in patients with non-alcoholic fatty liver and non-alcoholic steatohepatitis (NASH) (1.12+/-1.11, 1.49+/-2.16 and 0.68+/-0.4 ng/ml vs controls, respectively), independently from presence of type 2 diabetes mellitus. The increase was more marked in patients with NASH and in those with NAFL versus controls (p=0.001 and p=0.004, respectively), but not statistically different between the two groups (p=0.448). Finally, we found a statistically relevant increase of this marker in diabetic NAFLD patients compared to those non diabetic (1.56+/-0.81 vs 0.72+/-0.58 ng/ml; p=0.01).<br />Conclusion: We demonstrated an increased Endocan serum level in NAFLD patients, higher in those with type 2 diabetes mellitus and/or NASH because of an endothelial dysfunction in these pathologies.
- Subjects :
- Adult
Aged
Biomarkers blood
Diabetes Mellitus, Type 2 complications
Diabetes Mellitus, Type 2 diagnosis
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Middle Aged
Non-alcoholic Fatty Liver Disease complications
Non-alcoholic Fatty Liver Disease diagnosis
Pilot Projects
Up-Regulation
Diabetes Mellitus, Type 2 blood
Neoplasm Proteins blood
Non-alcoholic Fatty Liver Disease blood
Proteoglycans blood
Subjects
Details
- Language :
- English
- ISSN :
- 1842-1121
- Volume :
- 26
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of gastrointestinal and liver diseases : JGLD
- Publication Type :
- Academic Journal
- Accession number :
- 28922438
- Full Text :
- https://doi.org/10.15403/jgld.2014.1121.263.dal