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Tacrolimus Ointment for Refractory Posterior Blepharitis.
- Source :
-
Current eye research [Curr Eye Res] 2017 Nov; Vol. 42 (11), pp. 1440-1444. Date of Electronic Publication: 2017 Sep 18. - Publication Year :
- 2017
-
Abstract
- Purpose: This prospective, randomized, double-blind interventional case series was designed to evaluate the short-term efficacy of 0.03% tacrolimus ointment as a new therapeutic approach for refractory cases of posterior blepharitis.<br />Methods: Forty eyes (20 patients) with posterior blepharitis refractory to previous treatment were randomized. Eighteen eyes (9 patients) were treated with 0.03% tacrolimus ointment and 20 eyes (10 patients) with placebo ointment twice daily. Patients were evaluated with a questionnaire and slit-lamp examination 14 days and 28 days after treatment, and symptoms and signs of blepharitis were compared to those observed at baseline.<br />Results: We could observe statistical difference in the outcome measurements of meibomian gland secretion, conjunctival hyperemia, telangiectasia of inferior lid, Rose Bengal, and fluorescein scoring for the study group. As for the symptoms score, we observed statistical difference in the symptoms scoring for pruritus and dry eye sensation in the tacrolimus group.<br />Conclusion: This study suggests that topical administration of 0.03% tacrolimus ointment can improve some symptoms and some ocular surface status in patients with refractory posterior blepharitis.
- Subjects :
- Administration, Topical
Adult
Blepharitis pathology
Dose-Response Relationship, Drug
Double-Blind Method
Female
Follow-Up Studies
Humans
Immunosuppressive Agents administration & dosage
Male
Meibomian Glands drug effects
Middle Aged
Ointments
Prospective Studies
Slit Lamp Microscopy
Treatment Outcome
Blepharitis drug therapy
Meibomian Glands pathology
Tacrolimus administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2202
- Volume :
- 42
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Current eye research
- Publication Type :
- Academic Journal
- Accession number :
- 28922018
- Full Text :
- https://doi.org/10.1080/02713683.2017.1339805