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Inter-observer agreement in GTV delineation of bone metastases on CT and impact of MR imaging: A multicenter study.
- Source :
-
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2018 Mar; Vol. 126 (3), pp. 534-540. Date of Electronic Publication: 2017 Sep 14. - Publication Year :
- 2018
-
Abstract
- Background and Purpose: The use of Stereotactic Body Radiotherapy (SBRT) for bone metastases is increasing rapidly. Therefore, knowledge of the inter-observer differences in tumor volume delineation is essential to guarantee precise dose delivery. The aim of this study is to compare inter-observer agreement in bone metastases delineated on different imaging modalities.<br />Material and Methods: Twenty consecutive patients with bone metastases treated with SBRT were selected. All patients received CT and MR imaging in treatment position prior to SBRT. Five observers from three institutions independently delineated gross tumor volume (GTV) on CT alone, CT with co-registered MRI and MRI alone. Four contours per imaging modality per patient were available, as one set of contours was shared by 2 observers. Inter-observer agreement, expressed in generalized conformity index [CIgen], volumes of contours and contours center of mass (COM) were calculated per patient and imaging modality.<br />Results: Mean GTV delineated on MR (45.9±52.0cm <superscript>3</superscript> ) was significantly larger compared to CT-MR (40.2±49.4cm <superscript>3</superscript> ) and CT (34.8±41.8cm <superscript>3</superscript> ). A considerable variation in CIgen was found on CT (mean 0.46, range 0.15-0.75) and CT-MRI (mean 0.54, range 0.17-0.71). The highest agreement was found on MRI (mean 0.56, range 0.20-0.77). The largest variations of COM were found in anterior-posterior direction for all imaging modalities.<br />Conclusions: Large inter-observer variation in GTV delineation exists for CT, CT-MRI and MRI. MRI-based GTV delineation resulted in larger volumes and highest consistency between observers.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Subjects :
- Bone Neoplasms pathology
Cohort Studies
Humans
Magnetic Resonance Imaging methods
Magnetic Resonance Imaging standards
Observer Variation
Prospective Studies
Radiosurgery
Radiotherapy Planning, Computer-Assisted methods
Tomography, X-Ray Computed methods
Tomography, X-Ray Computed standards
Tumor Burden
Bone Neoplasms diagnostic imaging
Bone Neoplasms secondary
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0887
- Volume :
- 126
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 28919003
- Full Text :
- https://doi.org/10.1016/j.radonc.2017.08.030