Back to Search
Start Over
Horseradish and radish peroxidases eaten with fish could help explain observed associations between fish consumption and protection from age-related dementia.
- Source :
-
Medical hypotheses [Med Hypotheses] 2017 Sep; Vol. 107, pp. 5-8. Date of Electronic Publication: 2017 Jul 12. - Publication Year :
- 2017
-
Abstract
- A juxtaposition of regional cuisines and recent prospective studies of fish consumption in China and Japan points to fresh horseradish and/or radish (HRR) as possible contributors to delaying age-related dementia. The hypothesis is that the inverse association found sometimes between fish intake and cognitive decline is partially due to exposure of the oral cavity to active peroxidases from HRR served in conjunction with fish. This hypothesis can be tested by specifically looking at whether HRR is consumed with fish and whether such HRR is prepared in a way that preserves activity of HRR peroxidases. It is possible that by putting active HRR peroxidases in their mouths, elderly people supplement their age-diminished salivary antioxidant capacity and break down additional hydrogen peroxide (H <subscript>2</subscript> O <subscript>2</subscript> ) in the oral cavity before it can migrate into the brain, thus decreasing the incidence of brain cell death induction by chronically-elevated H <subscript>2</subscript> O <subscript>2</subscript> . Intentional exposure of the oral cavity to active HRR peroxidases could be a prophylactic for delaying dementia. Because vegetable peroxidases are inactivated by gastric juices, it will be difficult to obtain benefit from HRR peroxidases' antioxidant effect via ingestion in encapsulated dietary supplements.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)
- Subjects :
- Aged
Aging metabolism
Aging psychology
Animals
Antioxidants administration & dosage
Brain metabolism
China
Diet
Humans
Hydrogen Peroxide metabolism
Japan
Models, Biological
Mouth metabolism
Dementia prevention & control
Fishes
Horseradish Peroxidase administration & dosage
Peroxidases administration & dosage
Raphanus enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2777
- Volume :
- 107
- Database :
- MEDLINE
- Journal :
- Medical hypotheses
- Publication Type :
- Academic Journal
- Accession number :
- 28915962
- Full Text :
- https://doi.org/10.1016/j.mehy.2017.07.010