Back to Search
Start Over
Co-infection of human herpesvirus type 2 (HHV-2) and human immunodeficiency virus (HIV) among pregnant women in Rio de Janeiro, Brazil.
- Source :
-
AIDS care [AIDS Care] 2018 Mar; Vol. 30 (3), pp. 378-382. Date of Electronic Publication: 2017 Sep 15. - Publication Year :
- 2018
-
Abstract
- Pregnant women who are infected with the Human Immunodeficiency Virus (HIV) are particularly vulnerable to severe and recurrent infections with Human Herpesvirus 2 (HHV-2). Neonatal transmission of HHV-2 has been associated with malformations and neurological sequelae in infants, which makes it very important to perform antenatal monitoring for genital herpes. In the study, 134 pregnant women infected with HIV were tested for HHV-2 IgM and IgG using an enzyme-linked immunosorbent assay (ELISA) and had HHV-2 DNA analyzed by Real Time Polymerase Chain Reaction (qPCR). Fisher's exact test was applied to analyze the epidemiological dates (p < 0.05). A total of 59.7% of the pregnant women infected with HIV had HHV-2 IgG and 3.75% of them showed HHV-2 viremia. HHV-2 IgM was found in 6% of the pregnant women and 25% of them had HHV-2 viremia. The risk factors associated with HHV-2 seropositive were age under 20 and a CD4/CD8 ratio > 1. Our study found high HHV-2/HIV coinfection prevalence and HHV-2 viremia among patients with recurrent and primary genital infection, reinforcing the need of prevention and control of HHV-2 infection in order to avoid this virus transmission.
- Subjects :
- Adult
Antibodies, Viral blood
Brazil epidemiology
Enzyme-Linked Immunosorbent Assay
Female
HIV Infections epidemiology
Herpes Genitalis epidemiology
Humans
Polymerase Chain Reaction
Pregnancy
Pregnancy Complications, Infectious epidemiology
Pregnant Women
Prevalence
Young Adult
Coinfection epidemiology
HIV
HIV Infections diagnosis
Herpes Genitalis diagnosis
Herpesvirus 2, Human isolation & purification
Pregnancy Complications, Infectious virology
Subjects
Details
- Language :
- English
- ISSN :
- 1360-0451
- Volume :
- 30
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- AIDS care
- Publication Type :
- Academic Journal
- Accession number :
- 28914079
- Full Text :
- https://doi.org/10.1080/09540121.2017.1378798