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The SRGAP2 SNPs, their haplotypes and G × E interactions on serum lipid traits.
- Source :
-
Scientific reports [Sci Rep] 2017 Sep 14; Vol. 7 (1), pp. 11626. Date of Electronic Publication: 2017 Sep 14. - Publication Year :
- 2017
-
Abstract
- Maonan nationality is a relatively conservative and isolated minority in China. Little is known about the association of the Slit-Robo Rho GTPase activating protein 2 gene (SRGAP2) single nucleotide polymorphisms (SNPs) and serum lipid levels in the Chinese populations. This study was performed to clarify the association of the SRGAP2 rs2483058 and rs2580520 SNPs and their haplotypes with serum lipid traits in the Maonan and Han populations. Genotyping of the 2 SNPs was performed in 2444 unrelated subjects (Han, 1210 and Maonan, 1234) by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis, and then confirmed by direct sequencing. The allelic (rs2483058) and genotypic (rs2483058 and rs2580520) frequencies were different between the two ethnic groups. Four haplotypes were identified in our populations, and the rs2483058G-rs2580520C haplotype was the commonest one. The rs2483058C-rs2580520G haplotype was associated with an increased risk of dyslipidemia, and showed consistent association with serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), apolipoprotein (Apo) A1 levels, and the ApoA1/ApoB ratio. These results indicated that the SRGAP2 SNPs and their haplotypes were associated with serum lipid levels. Their haplotypes can explain much more serum lipid variation than any single SNP alone, especially for serum TC, HDL-C and ApoA1 levels.
- Subjects :
- Adult
Aged
Aged, 80 and over
Biomarkers
China epidemiology
China ethnology
Environmental Exposure
Female
Gene Frequency
Genotype
Humans
Life Style
Linkage Disequilibrium
Male
Middle Aged
Population Surveillance
Quantitative Trait, Heritable
Sequence Analysis, DNA
Alleles
GTPase-Activating Proteins genetics
Gene-Environment Interaction
Genetic Association Studies
Haplotypes
Lipids blood
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 28912560
- Full Text :
- https://doi.org/10.1038/s41598-017-10950-6