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Anti-VEGF treatment improves neurological function in tumors of the nervous system.
- Source :
-
Experimental neurology [Exp Neurol] 2018 Jan; Vol. 299 (Pt B), pp. 326-333. Date of Electronic Publication: 2017 Sep 11. - Publication Year :
- 2018
-
Abstract
- Research of various diseases of the nervous system has shown that VEGF has direct neuroprotective effects in the central and peripheral nervous systems, and indirect effects on improving neuronal vessel perfusion which leads to nerve protection. In the tumors of the nervous system, VEGF plays a critical role in tumor angiogenesis and tumor progression. The effect of anti-VEGF treatment on nerve protection and function has been recently reported - by normalizing the tumor vasculature, anti-VEGF treatment is able to relieve nerve edema and deliver oxygen more efficiently into the nerve, thus reducing nerve damage and improving nerve function. This review aims to summarize the divergent roles of VEGF in diseases of the nervous system and the recent findings of anti-VEGF therapy in nerve damage/regeneration and function in tumors, specifically, in Neurofibromatosis type 2 associated schwannomas.<br /> (Copyright © 2017. Published by Elsevier Inc.)
- Subjects :
- Animals
Antineoplastic Agents pharmacology
Cell Hypoxia drug effects
Central Nervous System Neoplasms blood supply
Disease Models, Animal
Disease Progression
Humans
Neoplasm Proteins physiology
Neovascularization, Pathologic etiology
Nerve Regeneration drug effects
Nervous System Diseases drug therapy
Nervous System Diseases physiopathology
Neuroma, Acoustic blood supply
Neuroma, Acoustic genetics
Peripheral Nervous System Neoplasms blood supply
Sciatic Nerve blood supply
Sciatic Nerve drug effects
Sciatic Nerve physiopathology
Signal Transduction
Vascular Endothelial Growth Factor A physiology
Antineoplastic Agents therapeutic use
Central Nervous System Neoplasms drug therapy
Molecular Targeted Therapy
Neoplasm Proteins antagonists & inhibitors
Neovascularization, Pathologic drug therapy
Neurofibromatosis 2
Neuroma, Acoustic drug therapy
Peripheral Nervous System Neoplasms drug therapy
Vascular Endothelial Growth Factor A antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2430
- Volume :
- 299
- Issue :
- Pt B
- Database :
- MEDLINE
- Journal :
- Experimental neurology
- Publication Type :
- Academic Journal
- Accession number :
- 28911884
- Full Text :
- https://doi.org/10.1016/j.expneurol.2017.09.008