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Association of silent infarcts in sickle cell anemia with decreased annexin A5 resistance.
- Source :
-
Blood cells, molecules & diseases [Blood Cells Mol Dis] 2018 Mar; Vol. 69, pp. 53-56. Date of Electronic Publication: 2017 Sep 04. - Publication Year :
- 2018
-
Abstract
- Background: Sickle cell anemia (SCA) is characterized by abnormally shaped, adhesive RBCs that interact with white blood cells and the endothelium, leading to chronic hemolysis, vasculopathy and a prothrombotic state. About 10% of subjects with a thrombotic event in the general population will have an associated antiphospholipid (aPL) antibody. One proposed mechanism for the thrombophilic nature of aPL antibodies is the disruption of the potent anticoagulant annexin A5 or Annexin A5 resistance (A5R). We designed a pilot study assessing the presence of aPL antibodies and disruption of A5R in pediatric sickle cell subjects.<br />Methods: 39 subjects with SCA participated in this study. A5R, DRVVT, anti-β2GP1, anti-β2GP1, anti-phosphatidylserine and anti-cardiolipin antibody assays were performed.<br />Results: There was a high prevalence of abnormal A5R despite a low prevalence of antiphospholipid antibodies. Multivariate logistic regression analyses showed an association with silent infarcts (p=0.015), lower hemoglobin (p=0.037), older age (p=0.047) and abnormal A5R.<br />Conclusion: We report an association between annexin A5 resistance and presence of silent infarct, low hemoglobin, and older age in a subgroup of SCA subjects. A potential role for perturbed A5R in the pathophysiology of SCA needs to be evaluated further.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Adult
Anemia, Sickle Cell immunology
Annexin A5 immunology
Anticoagulants blood
Anticoagulants immunology
Asymptomatic Diseases
Autoantibodies blood
Autoantibodies immunology
Biomarkers
Blood Coagulation
Blood Coagulation Tests
Child
Child, Preschool
Erythrocyte Indices
Female
Humans
Infarction diagnosis
Male
Odds Ratio
Young Adult
Anemia, Sickle Cell blood
Anemia, Sickle Cell complications
Annexin A5 blood
Infarction etiology
Infarction pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0961
- Volume :
- 69
- Database :
- MEDLINE
- Journal :
- Blood cells, molecules & diseases
- Publication Type :
- Academic Journal
- Accession number :
- 28911832
- Full Text :
- https://doi.org/10.1016/j.bcmd.2017.09.001