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Albendazole residues in goat's milk: Interferences in microbial inhibitor tests used to detect antibiotics in milk.
- Source :
-
Journal of food and drug analysis [J Food Drug Anal] 2017 Apr; Vol. 25 (2), pp. 302-305. Date of Electronic Publication: 2016 Nov 10. - Publication Year :
- 2017
-
Abstract
- Albendazole (ABZ) residues in goat's milk and their effect on the response of microbial inhibitor tests used for screening antibiotics were evaluated. A total of 18 Murciano-Granadina goats were treated with ABZ and individually milked once a day over a 7-day period. ABZ quantification was performed by high performance liquid chromatography. The ABZ parent drug was not detected. The maximum concentration of its metabolites (ABZ sulfoxide, ABZ sulfone, and ABZ 2-aminosulfone) was reached on the 1 <superscript>st</superscript> day post treatment (260.0 ± 70.1 μg/kg, 112.8 ± 28.7 μg/kg, 152.0 ± 23.6 μg/kg, respectively), decreasing to lower than the maximum residue limit (MRL, 100 μg/kg) on the 3 <superscript>rd</superscript> day post treatment. Milk samples were also analyzed by microbial tests [Brilliant Black Reduction Test (BRT) MRL, Delvotest SP-NT MCS and Eclipse 100], and only one positive result was found for Delvotest SP-NT MCS and Eclipse 100. However, a high occurrence of positive outcomes was obtained for BRT MRL during 6 days post treatment, whereas ABZ residues were not detected from the 4 <superscript>th</superscript> day post administration, suggesting that factors other than the antiparasitic agent might affect the microbial test response.<br /> (Copyright © 2016. Published by Elsevier B.V.)
- Subjects :
- Albendazole
Animals
Anti-Bacterial Agents
Drug Residues
Goats
Milk
Subjects
Details
- Language :
- English
- ISSN :
- 2224-6614
- Volume :
- 25
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of food and drug analysis
- Publication Type :
- Academic Journal
- Accession number :
- 28911671
- Full Text :
- https://doi.org/10.1016/j.jfda.2016.08.007