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Fatigue in multiple sclerosis: The contribution of resting-state functional connectivity reorganization.

Authors :
Bisecco A
Nardo FD
Docimo R
Caiazzo G
d'Ambrosio A
Bonavita S
Capuano R
Sinisi L
Cirillo M
Esposito F
Tedeschi G
Gallo A
Source :
Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2018 Nov; Vol. 24 (13), pp. 1696-1705. Date of Electronic Publication: 2017 Sep 15.
Publication Year :
2018

Abstract

Objectives: To investigate resting-state functional connectivity (RS-FC) of the default-mode network (DMN) and of sensorimotor network (SMN) network in relapsing remitting (RR) multiple sclerosis (MS) patients with fatigue (F) and without fatigue(NF).<br />Methods: In all, 59 RRMS patients and 29 healthy controls (HC) underwent magnetic resonance imaging (MRI) protocol including resting-state fMRI (RS-fMRI). Functional connectivity of the DMN and SMN was evaluated by independent component analysis (ICA). A linear regression analysis was performed to explore whether fatigue was mainly driven by changes observed in the DMN or in the SMN. Regional gray matter atrophy was assessed by voxel-based morphometry (VBM).<br />Results: Compared to HC, F-MS patients showed a stronger RS-FC in the posterior cingulate cortex (PCC) and a reduced RS-FC in the anterior cingulated cortex (ACC) of the DMN. F-MS patients, compared to NF-MS patients, revealed (1) an increased RS-FC in the PCC and a reduced RS-FC in the ACC of the DMN and (2) an increased RS-FC in the primary motor cortex and in the supplementary motor cortex of the SMN. The regression analysis suggested that fatigue is mainly driven by RS-FC changes of the DMN.<br />Conclusions: Fatigue in RRMS is mainly associated to a functional rearrangement of non-motor RS networks.

Details

Language :
English
ISSN :
1477-0970
Volume :
24
Issue :
13
Database :
MEDLINE
Journal :
Multiple sclerosis (Houndmills, Basingstoke, England)
Publication Type :
Academic Journal
Accession number :
28911257
Full Text :
https://doi.org/10.1177/1352458517730932