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Genetic variants in PPP2CA are associated with gastric cancer risk in a Chinese population.
- Source :
-
Scientific reports [Sci Rep] 2017 Sep 13; Vol. 7 (1), pp. 11499. Date of Electronic Publication: 2017 Sep 13. - Publication Year :
- 2017
-
Abstract
- Protein phosphatase 2A (PP2A), a tumor suppressor protein, has been implicated in cell cycle and apoptosis. Additionally, studies have illustrated its crucial roles in transformation of normal human cells to tumorigenic status. PPP2CA, which encodes the alpha isoform of the catalytic subunit of PP2A, has been recently reported to be associated with several types of cancers. Therefore, we hypothesized that genetic variants in PPP2CA might influence susceptibility of gastric cancer. To test this hypothesis, three tagging single nucleotide polymorphisms (SNPs) in PPP2CA were genotyped in a case-control study including 1,113 cases and 1,848 controls in a Chinese population. Three tagging SNPs in PPP2CA were genotyped using Illumina Human Exome BeadChip. We observed that the A allele of rs13187105 was associated with an increased risk of gastric cancer (adjusted odds ratio (OR) = 1.14, 95% confidence interval (CI): 1.02-1.28, P = 0.017). Further analyses showed that rs13187105 [A] was associated with decreased expression of PPP2CA mRNA (P = 5.1 × 10 <superscript>-6</superscript> ), and PPP2CA mRNA was significantly lower in gastric tumor tissues when comparing that in their adjacent normal tissues (P = 0.037). These findings support our hypothesis that genetic variants in PPP2CA may be implicated in gastric cancer susceptibility in Chinese population.
- Subjects :
- Alleles
Case-Control Studies
China epidemiology
Databases, Genetic
Female
Gene Frequency
Genotype
Humans
Male
Odds Ratio
Polymorphism, Single Nucleotide
Population Surveillance
Quantitative Trait Loci
Asian People genetics
Genetic Predisposition to Disease
Genetic Variation
Protein Phosphatase 2 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 28904398
- Full Text :
- https://doi.org/10.1038/s41598-017-12040-z