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Brachioradial Pruritus and Notalgia Paraesthetica: A Comparative Observational Study of Clinical Presentation and Morphological Pathologies.
- Source :
-
Acta dermato-venereologica [Acta Derm Venereol] 2018 Jan 12; Vol. 98 (1), pp. 82-88. - Publication Year :
- 2018
-
Abstract
- Brachioradial pruritus (BRP) and notalgia paraesthetica (NP) represent 2 of the most common neuropathic itch syndromes. A total of 58 consecutive patients presenting at the Center for Chronic Pruritus, University Hospital Münster, were analysed with regard to clinical presentation, anatomical and morphological pathologies, impairment in quality of life, and response to treatment with topical capsaicin. Patients with BRP reported stinging and burning more often than those with NP. In the BRP group structural magnetic resonance imaging abnormalities more frequently correlated with localization of the symptoms compared with in patients with NP. In addition, intraepidermal nerve fibre density was decreased in lesional skin in patients with BRP, but not in those with NP, confirming the neuropathic origin in BRP. Topical capsaicin resulted in a significantly higher alleviation of itch and pain intensity and improvement in quality of life in patients with BRP compared with those with NP, which may reflect clinical and aetiological differences between the conditions.
- Subjects :
- Aged
Antipruritics administration & dosage
Back
Capsaicin administration & dosage
Cervical Vertebrae
Female
Forearm
Ganglia, Spinal
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Nerve Compression Syndromes diagnostic imaging
Paresthesia drug therapy
Pruritus drug therapy
Quality of Life
Retrospective Studies
Skin innervation
Spinal Cord Compression complications
Spinal Cord Compression diagnostic imaging
Spinal Nerves
Thoracic Vertebrae
Transdermal Patch
Nerve Compression Syndromes complications
Paresthesia etiology
Pruritus etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1651-2057
- Volume :
- 98
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Acta dermato-venereologica
- Publication Type :
- Academic Journal
- Accession number :
- 28902951
- Full Text :
- https://doi.org/10.2340/00015555-2789