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Anti-carbamylated protein antibodies in rheumatoid arthritis patients and their association with rheumatoid factor.
- Source :
-
Saudi medical journal [Saudi Med J] 2017 Sep; Vol. 38 (9), pp. 934-941. - Publication Year :
- 2017
-
Abstract
- Objectives: To evaluate levels of anti-carbamylated protein (anti-CarP) antibodies in rheumatoid arthritis (RA) patients and to determine their association with serological parameters and disease activity. Methods: A cross-sectional study involving 105 multiethnic RA patients (48 rheumatoid factor [RF]-positive and 57 RF-negative patients) was conducted at Hospital Universiti Sains Malaysia, Kelantan, Malaysia, from January 2015 to February 2016. Fifty healthy controls (HCs) were included. C-reactive protein (CRP), RF, anti-cyclic citrullinated peptide (anti-CCP) and anti-CarP antibodies were measured. A health assessment questionnaire (HAQ) was administered to the study participants and 28-joint Disease Activity Score (DAS28) were obtained. Results: The level of anti-CarP antibodies was significantly increased in the RA patients compared with HCs (p=0.042). The presence of anti-CarP antibodies was significantly associated with RF (p=0.019) and the HAQ (p=0.010). A significant association between the presence of anti-CarP antibodies and the DAS28 was not found (p=0.632). Conclusion: Our study provides further evidence that the level of anti-CarP antibodies is significantly elevated in RA patients.
Details
- Language :
- English
- ISSN :
- 0379-5284
- Volume :
- 38
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Saudi medical journal
- Publication Type :
- Academic Journal
- Accession number :
- 28889152
- Full Text :
- https://doi.org/10.15537/smj.2017.9.20841