Back to Search
Start Over
A charge-reversible nanocarrier using PEG-PLL (- g -Ce6, DMA)-PLA for photodynamic therapy.
A charge-reversible nanocarrier using PEG-PLL (- g -Ce6, DMA)-PLA for photodynamic therapy.
- Source :
-
International journal of nanomedicine [Int J Nanomedicine] 2017 Aug 24; Vol. 12, pp. 6185-6196. Date of Electronic Publication: 2017 Aug 24 (Print Publication: 2017). - Publication Year :
- 2017
-
Abstract
- A polyelectrolyte nanoparticle composed of PEG-PLL(- g -Ce6, DMA)-PLA was developed for nanomedicinal application in photodynamic therapy. These nanoparticles formed stable aggregates through the hydrophobic interaction of poly(lactic acid) and demonstrated pH-dependent behaviors such as surface charge conversion and enhanced cellular uptake at acidic pH, resulting in improved phototoxicity. In vivo animal imaging revealed that the prepared PEG-PLL(- g -Ce6, DMA)-PLA nanoparticles effectively accumulated at the targeted tumor site through enhanced permeability and retention effects. Reversible surface charge for PEG-PLL (- g -Ce6, DMA)-PLA nanoparticles allows the nanoparticles to escape the immune system and concentrate on the tumor tissue. Tumor growth in the nude mice treated with the nanoparticles decreased significantly and the hydrophobic interaction in the poly(lactic acid) block could allow the incorporation of multiple drugs. Therefore, the PEG-PLL(- g -Ce6, DMA)-PLA nanoparticles could have considerable potential as a nanomedicinal platform for photodynamic therapy.<br />Competing Interests: Disclosure The authors report no conflicts of interest in this work.
- Subjects :
- Animals
Chlorophyllides
Female
Humans
Hydrogen-Ion Concentration
Hydrophobic and Hydrophilic Interactions
KB Cells
Maleic Anhydrides chemistry
Mice, Inbred BALB C
Mice, Nude
Neoplasms drug therapy
Polyesters chemistry
Polyethylene Glycols chemistry
Polylysine analogs & derivatives
Polylysine chemistry
Porphyrins chemistry
Drug Carriers chemistry
Nanoparticles chemistry
Photochemotherapy methods
Photosensitizing Agents chemistry
Photosensitizing Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1178-2013
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- International journal of nanomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 28883728
- Full Text :
- https://doi.org/10.2147/IJN.S142912