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A charge-reversible nanocarrier using PEG-PLL (- g -Ce6, DMA)-PLA for photodynamic therapy.

A charge-reversible nanocarrier using PEG-PLL (- g -Ce6, DMA)-PLA for photodynamic therapy.

Authors :
Lim C
Sim T
Hoang NH
Jung CE
Lee ES
Youn YS
Oh KT
Source :
International journal of nanomedicine [Int J Nanomedicine] 2017 Aug 24; Vol. 12, pp. 6185-6196. Date of Electronic Publication: 2017 Aug 24 (Print Publication: 2017).
Publication Year :
2017

Abstract

A polyelectrolyte nanoparticle composed of PEG-PLL(- g -Ce6, DMA)-PLA was developed for nanomedicinal application in photodynamic therapy. These nanoparticles formed stable aggregates through the hydrophobic interaction of poly(lactic acid) and demonstrated pH-dependent behaviors such as surface charge conversion and enhanced cellular uptake at acidic pH, resulting in improved phototoxicity. In vivo animal imaging revealed that the prepared PEG-PLL(- g -Ce6, DMA)-PLA nanoparticles effectively accumulated at the targeted tumor site through enhanced permeability and retention effects. Reversible surface charge for PEG-PLL (- g -Ce6, DMA)-PLA nanoparticles allows the nanoparticles to escape the immune system and concentrate on the tumor tissue. Tumor growth in the nude mice treated with the nanoparticles decreased significantly and the hydrophobic interaction in the poly(lactic acid) block could allow the incorporation of multiple drugs. Therefore, the PEG-PLL(- g -Ce6, DMA)-PLA nanoparticles could have considerable potential as a nanomedicinal platform for photodynamic therapy.<br />Competing Interests: Disclosure The authors report no conflicts of interest in this work.

Details

Language :
English
ISSN :
1178-2013
Volume :
12
Database :
MEDLINE
Journal :
International journal of nanomedicine
Publication Type :
Academic Journal
Accession number :
28883728
Full Text :
https://doi.org/10.2147/IJN.S142912