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Mechanisms underlying the small intestinal fluid secretion caused by arachidonic acid, prostaglandin E1 and prostaglandin E2 in the rat in vivo.
- Source :
-
Acta physiologica Scandinavica [Acta Physiol Scand] 1987 Aug; Vol. 130 (4), pp. 633-42. - Publication Year :
- 1987
-
Abstract
- Prostanoids were given intraluminally (PGE2) or infused close intra-arterially (PGE1 and PGE2) or arachidonic acid was administered intraluminally to denervated jejunal segments of the rat in vivo. These experimental manoeuvres caused a net fluid secretion, although a 1,000-fold higher concentration of the prostanoids was needed from the luminal than from the vascular side. I.v. hexamethonium or serosally applied lidocaine diminished the induced fluid secretion suggesting that the prostanoids act mainly by eliciting local secretory reflexes in the enteric nervous system. This nerve-mediated secretion is not accompanied by any increase in tissue cAMP. However, at higher i.a. concentrations of PGE2 there seems to be a non-neurogenic effect on the enterocytes associated with an increase in tissue cAMP.
- Subjects :
- Alprostadil administration & dosage
Animals
Arachidonic Acid
Atropine administration & dosage
Body Water metabolism
Cyclic AMP metabolism
Denervation
Dinoprostone
Hexamethonium
Hexamethonium Compounds administration & dosage
Injections, Intra-Arterial
Intestinal Absorption drug effects
Male
Rats
Rats, Inbred Strains
Alprostadil analogs & derivatives
Arachidonic Acids administration & dosage
Intestinal Secretions drug effects
Jejunum drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0001-6772
- Volume :
- 130
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Acta physiologica Scandinavica
- Publication Type :
- Academic Journal
- Accession number :
- 2888261
- Full Text :
- https://doi.org/10.1111/j.1748-1716.1987.tb08186.x