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Activity of 3'-hydroxychalcone against Cryptococcus gattii and toxicity, and efficacy in alternative animal models.
- Source :
-
Future microbiology [Future Microbiol] 2017 Oct; Vol. 12, pp. 1123-1134. Date of Electronic Publication: 2017 Sep 06. - Publication Year :
- 2017
-
Abstract
- Aim: This work aimed to evaluate the activity of 3'-hydroxychalcone against Cryptococcus gattii in planktonic and biofilm forms and their toxicity using alternative animal models.<br />Materials & Methods: Minimum inhibitory concentration and minimum fungicide concentration were determined. Biofilm formation and the susceptibility tests were performed by the 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-5-[carbonyl(phenylamino)]-2H-tetrazolium hydroxide assay. Toxicity and efficacy were checked in Danio rerio and Galleria mellonella models.<br />Results: The compound 3'-hydroxychalcone showed fungicidal activity against C. gattii in both planktonic and biofilm forms. The toxicity in zebrafish embryos revealed a low lethal concentration. In G. mellonella, the compound did not show antifungal activity and larvae toxicity.<br />Conclusion: Because of the activity of 3'-hydroxychalcone against C. gattii in vitro, molecular modifications should be made to improve efficacy and to reduce toxicity in vivo. [Formula: see text].
- Subjects :
- Animals
Antifungal Agents chemistry
Biofilms drug effects
Cryptococcosis microbiology
Cryptococcus gattii cytology
Lepidoptera drug effects
Microbial Sensitivity Tests
Microscopy, Electron, Scanning
Zebrafish
Antifungal Agents pharmacology
Cryptococcus gattii drug effects
Disease Models, Animal
Subjects
Details
- Language :
- English
- ISSN :
- 1746-0921
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- Future microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 28876122
- Full Text :
- https://doi.org/10.2217/fmb-2017-0062