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Subinhibitory Dalbavancin Attenuates Exotoxin Production from Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus In Vitro .
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2017 Oct 24; Vol. 61 (11). Date of Electronic Publication: 2017 Oct 24 (Print Publication: 2017). - Publication Year :
- 2017
-
Abstract
- This study investigated the effects of subinhibitory doses of the lipoglycopeptide antibiotic dalbavancin on Staphylococcus aureus toxin production in vitro S. aureus toxin production levels were compared to those seen with the natural glycopeptide antibiotic vancomycin and with representative beta-lactam and oxazolidinone antibiotics. While neither dalbavancin nor vancomycin adversely affected toxin production, of these glycopeptide antibiotics, only dalbavancin significantly attenuated toxin production at subinhibitory concentrations. These findings support the recent success of dalbavancin for treatment of staphylococcal infections.<br /> (Copyright © 2017 American Society for Microbiology.)
- Subjects :
- Anti-Bacterial Agents administration & dosage
Dose-Response Relationship, Drug
Methicillin-Resistant Staphylococcus aureus drug effects
Microbial Sensitivity Tests
Oxazolidinones pharmacology
Staphylococcus aureus metabolism
Staphylococcus aureus physiology
Teicoplanin administration & dosage
Teicoplanin pharmacology
Vancomycin pharmacology
Anti-Bacterial Agents pharmacology
Enterotoxins metabolism
Staphylococcus aureus drug effects
Teicoplanin analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1098-6596
- Volume :
- 61
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 28874375
- Full Text :
- https://doi.org/10.1128/AAC.01090-17