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Repeated administration of (-)sulpiride and SCH 23390 differentially up-regulate D-1 and D-2 dopamine receptor function in rat mesostriatal areas but not in cortical-limbic brain regions.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 1987 Jun 12; Vol. 138 (1), pp. 45-51. - Publication Year :
- 1987
-
Abstract
- We studied the possible functional modifications of both D-1 and D-2 dopamine (DA) receptor subtypes following repeated administration of DA antagonists that act selectively on a single class of DA receptors. The functional state of D-1 and D-2 DA receptors in particular was evaluated by measuring SKF 82526-stimulated and bromocriptine-inhibited adenylate cyclase activity in different brain regions of rats treated with saline, SCH 23390, or (-)sulpiride for 21 days. The results indicate that chronic blockade of D-1 DA receptors in striatum, nucleus accumbens, and substantia nigra by SCH 23390 induced up-regulation of the D-1 receptors without changing the functional activity of D-2 receptors. Likewise, chronic blockade of D-2 DA receptors by (-)sulpiride caused up-regulation of D-2 but not D-1 DA receptors in striatum, nucleus accumbens, substantia nigra and pituitary. SCH 23390 or (-)sulpiride did not modify the functional activity of either D-1 or D-2 DA receptors located in frontal cortex and hippocampus. In conclusion, these results indicate that chronic treatment with selective D-1 or D-2 DA receptor blockers induces a receptor-specific up-regulation which involves the DA receptors located in the nigrostriatal system and pituitary but not those in the limbic-cortical areas.
- Subjects :
- Adenylyl Cyclases metabolism
Animals
Brain enzymology
Bromocriptine pharmacology
Cerebral Cortex drug effects
Cerebral Cortex enzymology
Corpus Striatum drug effects
Corpus Striatum enzymology
Fenoldopam
Limbic System drug effects
Limbic System enzymology
Male
Pituitary Gland drug effects
Pituitary Gland metabolism
Rats
Rats, Inbred Strains
Vasodilator Agents pharmacology
Antipsychotic Agents pharmacology
Benzazepines pharmacology
Brain drug effects
Receptors, Dopamine drug effects
Sulpiride pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2999
- Volume :
- 138
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 2887436
- Full Text :
- https://doi.org/10.1016/0014-2999(87)90335-9