Back to Search Start Over

Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age.

Authors :
Teague WG
Phillips BR
Fahy JV
Wenzel SE
Fitzpatrick AM
Moore WC
Hastie AT
Bleecker ER
Meyers DA
Peters SP
Castro M
Coverstone AM
Bacharier LB
Ly NP
Peters MC
Denlinger LC
Ramratnam S
Sorkness RL
Gaston BM
Erzurum SC
Comhair SAA
Myers RE
Zein J
DeBoer MD
Irani AM
Israel E
Levy B
Cardet JC
Phipatanakul W
Gaffin JM
Holguin F
Fajt ML
Aujla SJ
Mauger DT
Jarjour NN
Source :
The journal of allergy and clinical immunology. In practice [J Allergy Clin Immunol Pract] 2018 Mar - Apr; Vol. 6 (2), pp. 545-554.e4. Date of Electronic Publication: 2017 Aug 31.
Publication Year :
2018

Abstract

Background: The effect of age on asthma severity is poorly understood.<br />Objectives: The objective of this study was to compare the baseline features of severe and nonsevere asthma in the Severe Asthma Research Program (SARP) III cohort, and examine in cross section the effects of age on those features.<br />Methods: SARP III is a National Institutes of Health/National Heart Lung Blood Institute multisite 3-year cohort study conducted to investigate mechanisms of severe asthma. The sample included 188 children (111 severe, 77 nonsevere) and 526 adults (313 severe, 213 nonsevere) characterized for demographic features, symptoms, health care utilization, lung function, and inflammatory markers compared by age and severity.<br />Results: Compared with children with nonsevere asthma, children with severe asthma had more symptoms and more historical exacerbations, but no difference in body weight, post-bronchodilator lung function, or inflammatory markers. After childhood, and increasing with age, the cohort had a higher proportion of women, less allergen sensitization, and overall fewer blood eosinophils. Enrollment of participants with severe asthma was highest in middle-aged adults, who were older, more obese, with greater airflow limitation and higher blood eosinophils, but less allergen sensitization than adults with nonsevere asthma.<br />Conclusions: The phenotypic features of asthma differ by severity and with advancing age. With advancing age, patients with severe asthma are more obese, have greater airflow limitation, less allergen sensitization, and variable type 2 inflammation. Novel mechanisms besides type 2 inflammatory pathways may inform the severe asthma phenotype with advancing age.<br /> (Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
2213-2201
Volume :
6
Issue :
2
Database :
MEDLINE
Journal :
The journal of allergy and clinical immunology. In practice
Publication Type :
Academic Journal
Accession number :
28866107
Full Text :
https://doi.org/10.1016/j.jaip.2017.05.032