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Molecular evidence for the absence of an association between Simkania negevensis and respiratory diseases.
- Source :
-
Journal of medical microbiology [J Med Microbiol] 2017 Sep; Vol. 66 (9), pp. 1324-1327. Date of Electronic Publication: 2017 Aug 31. - Publication Year :
- 2017
-
Abstract
- Simkania negevensis has been implicated in respiratory diseases. This study aimed to unveil the aetiological role of this bacterium in community-acquired pneumonia (CAP) and bronchitis in Jordanian adults. Nasopharyngeal samples were collected from 98 CAP or bronchitis patients and 96 control individuals, and tested for Simkania nucleic acids using a PCR assay. The overall prevalence of the bacterial DNA in patients was markedly high and reached 57.1 %. Intriguingly, Simkania DNA was detected in 62.5 % of the nasopharyngeal swabs collected from apparently healthy controls (P>0.05). The DNA positivity in the bronchitis and CAP subgroups was 57.7 and 56.9 %, respectively, percentages that are approximately comparable to the DNA positivity assessed for the entire patient population. Simkania is most likely not a causative agent of CAP or bronchitis, despite its remarkable high prevalence. This organism, in the nasopharynx, is potentially harmless to the host and may coexist in a commensal relationship.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Bacterial blood
Chlamydiales genetics
Chlamydiales immunology
DNA, Bacterial genetics
Female
Humans
Immunoglobulin G blood
Jordan
Male
Middle Aged
Polymerase Chain Reaction
Young Adult
Bronchitis microbiology
Chlamydiales isolation & purification
Community-Acquired Infections microbiology
Nasopharynx microbiology
Pneumonia microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5644
- Volume :
- 66
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of medical microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 28857732
- Full Text :
- https://doi.org/10.1099/jmm.0.000564