Back to Search
Start Over
A genome-wide association analysis identifies NMNAT2 and HCP5 as susceptibility loci for Kawasaki disease.
- Source :
-
Journal of human genetics [J Hum Genet] 2017 Dec; Vol. 62 (12), pp. 1023-1029. Date of Electronic Publication: 2017 Aug 31. - Publication Year :
- 2017
-
Abstract
- Kawasaki disease (KD), a systemic vasculitis of infants and children, manifests as fever and mucocutaneous inflammation. Although its etiology is largely unknown, the epidemiological data suggest that genetic factors are important in KD susceptibility. To identify genetic variants influencing KD susceptibility, we performed a genome-wide association study (GWAS) and replication study using a total of 915 children with KD and 4553 controls in the Korean population. Six single-nucleotide polymorphisms (SNPs) in three loci were associated significantly with KD susceptibility (P<1.0 × 10 <superscript>-5</superscript> ), including the previously reported BLK locus (rs6993775, odds ratio (OR)=1.52, P=2.52 × 10 <superscript>-11</superscript> ). The other two loci were newly identified: NMNAT2 on chromosome 1q25.3 (rs2078087, OR=1.33, P=1.15 × 10 <superscript>-6</superscript> ) and the human leukocyte antigen (HLA) region on chromosome 6p21.3 (HLA-C, HLA-B, MICA and HCP5) (rs9380242, rs9378199, rs9266669 and rs6938467; OR=1.33-1.51, P=8.93 × 10 <superscript>-6</superscript> to 5.24 × 10 <superscript>-8</superscript> ). Additionally, SNP rs17280682 in NLRP14 was associated significantly with KD with a family history (18 cases vs 4553 controls, OR=6.76, P=5.46 × 10 <superscript>-6</superscript> ). These results provide new insights into the pathogenesis and pathophysiology of KD.
- Subjects :
- Child
Genetic Loci genetics
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Humans
Mucocutaneous Lymph Node Syndrome physiopathology
Nucleoside-Triphosphatase genetics
Odds Ratio
Republic of Korea
Histocompatibility Antigens Class I genetics
Mucocutaneous Lymph Node Syndrome genetics
Nicotinamide-Nucleotide Adenylyltransferase genetics
Polymorphism, Single Nucleotide genetics
RNA, Long Noncoding genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1435-232X
- Volume :
- 62
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of human genetics
- Publication Type :
- Academic Journal
- Accession number :
- 28855716
- Full Text :
- https://doi.org/10.1038/jhg.2017.87