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Increased levels of sodium chloride directly increase osteoclastic differentiation and resorption in mice and men.
- Source :
-
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [Osteoporos Int] 2017 Nov; Vol. 28 (11), pp. 3215-3228. Date of Electronic Publication: 2017 Aug 29. - Publication Year :
- 2017
-
Abstract
- To better understand the association between high salt intake and osteoporosis, we investigated the effect of sodium chloride (NaCl) on mice and human osteoclastogenesis. The results suggest a direct, activating role of NaCl supplementation on bone resorption.<br />Introduction: High NaCl intake is associated with increased urinary calcium elimination and parathyroid hormone (PTH) secretion which in turn stimulates the release of calcium from the bone, resulting in increased bone resorption. However, while calciuria after NaCl loading could be shown repeatedly, several studies failed to reveal a significant increase in PTH in response to a high-sodium diet. Another possible explanation that we investigated here could be a direct effect of high-sodium concentration on bone resorption.<br />Methods: Mouse bone marrow macrophage and human peripheral blood mononuclear cells (PBMC) driven towards an osteoclastogenesis pathway were cultivated under culture conditions mimicking hypernatremia environments.<br />Results: In this study, a direct effect of increased NaCl concentrations on mouse osteoclast differentiation and function was observed. Surprisingly, in a human osteoclast culture system, significant increases in the number of tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts, calcitonin receptor (CTR)-positive osteoclasts, nuclear factor-activated T cells c1 (NFATc1) gene expression, and areal and volumetric resorptions were observed for increasing concentrations of NaCl. This suggests a direct, activating, cell-mediated effect of increased concentrations of NaCl on osteoclasts.<br />Conclusions: The reported that enhanced bone resorption after high-sodium diets may not only be secondary to the urinary calcium loss but may also be a direct, cell-mediated effect on osteoclastic resorption. These findings allow us to suggest an explanation for the clinical findings independent of a PTH-mediated regulation.
- Subjects :
- Animals
Bone Resorption chemically induced
Bone Resorption metabolism
Bone Resorption physiopathology
Cell Differentiation drug effects
Cells, Cultured
Dose-Response Relationship, Drug
Humans
Mice
Osteoclasts cytology
Osteoclasts metabolism
Receptors, Calcitonin metabolism
Sodium Chloride administration & dosage
Tartrate-Resistant Acid Phosphatase metabolism
Osteoclasts drug effects
Osteogenesis drug effects
Sodium Chloride pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1433-2965
- Volume :
- 28
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
- Publication Type :
- Academic Journal
- Accession number :
- 28849275
- Full Text :
- https://doi.org/10.1007/s00198-017-4163-4