Back to Search
Start Over
IFN-λ suppresses intestinal inflammation by non-translational regulation of neutrophil function.
- Source :
-
Nature immunology [Nat Immunol] 2017 Oct; Vol. 18 (10), pp. 1084-1093. Date of Electronic Publication: 2017 Aug 28. - Publication Year :
- 2017
-
Abstract
- Interferon-λ (IFN-λ) is a central regulator of mucosal immunity; however, its signaling specificity relative to that of type I interferons is poorly defined. IFN-λ can induce antiviral interferon-stimulated genes (ISGs) in epithelia, while the effect of IFN-λ in non-epithelial cells remains unclear. Here we report that neutrophils responded to IFN-λ. We found that in addition to inducing ISG transcription, IFN-λ (but not IFN-β) specifically activated a translation-independent signaling pathway that diminished the production of reactive oxygen species and degranulation in neutrophils. In mice, IFN-λ was elicited by enteric viruses and acted on neutrophils to decrease oxidative stress and intestinal damage. Thus, IFN-λ acted as a unique immunomodulatory agent by modifying transcriptional and non-translational neutrophil responses, which might permit a controlled development of the inflammatory process.
- Subjects :
- Animals
Cluster Analysis
Disease Models, Animal
Gastroenteritis pathology
Gene Expression
Gene Expression Profiling
Gene Expression Regulation
Genetic Predisposition to Disease
Humans
Intestinal Mucosa immunology
Intestinal Mucosa microbiology
Intestinal Mucosa pathology
Intestines pathology
Mice
Mice, Knockout
Microbiota
Oxidative Stress
Receptors, Cytokine genetics
Receptors, Cytokine metabolism
Gastroenteritis etiology
Gastroenteritis metabolism
Interferon-gamma metabolism
Intestinal Mucosa metabolism
Intestines immunology
Neutrophils immunology
Neutrophils metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1529-2916
- Volume :
- 18
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Nature immunology
- Publication Type :
- Academic Journal
- Accession number :
- 28846084
- Full Text :
- https://doi.org/10.1038/ni.3821