Case report: Coxiella burnetii vascular infection and lymphoma in the Netherlands.

Authors :: van Roeden SE
Melenotte C
Hermans MHA
Sinnige HAM
Nooijen PTGA
Audoly G
Hoepelman AIM
Oosterheert JJ
Raoult D
Wever PC
Source :: Infection [Infection] 2018 Feb; Vol. 46 (1), pp. 131-134. Date of Electronic Publication: 2017 Aug 24.
Publication Year :: 2018
Abstract: Objectives and Design: Non-Hodgkin lymphoma has been linked to infection with Coxiella burnetii, potentially through overproduction of IL-10 during infection with C. burnetii.<br />Materials and Methods: Description of a case report.<br />Results: We describe a patient with retroperitoneal non-Hodgkin lymphoma and vascular infection with C. burnetii. Immunofluorescence staining and fluorescence in situ hybridization targeting specific C. burnetii 16S rRNA were performed on the retroperitoneal lymphoma tissue sample obtained at diagnosis of NHL. Both were strongly positive for the presence of C. burnetii.<br />Conclusions: This case provokes questions regarding a potential association between C. burnetii and NHL, and underlines the importance of further exploration of this association.

Subjects :: Coxiella burnetii genetics
Fluorescent Antibody Technique
Humans
In Situ Hybridization, Fluorescence
Lymphoma, Non-Hodgkin microbiology
Male
Middle Aged
Netherlands
Q Fever microbiology
RNA, Bacterial analysis
RNA, Ribosomal, 16S analysis
Retroperitoneal Neoplasms microbiology
Coxiella burnetii isolation & purification
Lymphoma, Non-Hodgkin diagnosis
Q Fever diagnosis
Retroperitoneal Neoplasms diagnosis

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