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Emergence and clonal transmission of multi-drug-resistant tuberculosis among patients in Chad.
- Source :
-
BMC infectious diseases [BMC Infect Dis] 2017 Aug 22; Vol. 17 (1), pp. 579. Date of Electronic Publication: 2017 Aug 22. - Publication Year :
- 2017
-
Abstract
- Background: Emergence of Multidrug-resistant (MDR) strains constitutes a significant public health problem worldwide. Prevalence of MDR tuberculosis from Chad is unavailable to date.<br />Methods: We collected samples from consecutive TB patients nationwide in the seven major cities of Chad between 2007 and 2012 to characterize drug resistance and the population structure of circulating Mycobacterium tuberculosis complex (MTBC) strains. We tested drug sensitivity using Line Probe Assays and phenotypic drug susceptibility testing (DST) were used for second line drugs. We genotyped the isolates using spoligotype analysis and MIRU-VNTR.<br />Results: A total of 311 cultures were isolated from 593 patients. The MDR prevalence was 0.9% among new patients and 3.5% among retreatment patients, and no second line drug resistance was identified. The distribution of genotypes suggests a dissemination of MDR strains in the Southern city of Moundou, bordering Cameroon and Central African Republic.<br />Conclusion: Emerging MDR isolates pose a public health threat to Southern Chad, with risk to neighboring countries. This study informs public health practitioners, justifying the implementation of continuous surveillance with DST for all retreatment cases as well as contacts of MDR patients, in parallel with provision of adequate 2nd line regimens in the region.
- Subjects :
- Antitubercular Agents pharmacology
Chad epidemiology
Clone Cells
Communicable Diseases, Emerging epidemiology
Communicable Diseases, Emerging transmission
Female
Genotype
Humans
Male
Middle Aged
Mycobacterium tuberculosis drug effects
Mycobacterium tuberculosis genetics
Prevalence
Tuberculosis, Multidrug-Resistant epidemiology
Tuberculosis, Multidrug-Resistant transmission
Communicable Diseases, Emerging microbiology
Drug Resistance, Multiple, Bacterial
Genetic Variation
Mycobacterium tuberculosis isolation & purification
Tuberculosis, Multidrug-Resistant microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2334
- Volume :
- 17
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 28830384
- Full Text :
- https://doi.org/10.1186/s12879-017-2671-7